Orofacial neuropathy and pain in cancer patients

Yehuda Zadik, Noam Yarom, Sharon Elad

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations


The orofacial region, which includes the lower half of the face and the oral cavity, commonly causes oncologic patients to seek medical attention for pain. Orofacial pain is unique because its potential influence is much wider than pain in other regions of the body. Orofacial pain impairs: (1) orofacial functions such as eating, drinking, speaking, and facial expression; (2) quality of life; and (3) the ability to maintain adequate oral hygiene, which might result in the deterioration of oral health (teeth and gums) and halitosis. These difficulties may have a significant medical, nutritional, functional, or social-psychological impact in the cancer patient, especially during periods of cytotoxic chemotherapy-related neutropenia. The debilitating effects of orofacial pain may limit the administration of anticancer chemotherapy or cause other treatment modifications (e.g., percutaneous endoscopic gastrostomy for feeding). Furthermore, orofacial neuropathies manifesting as parasthesia may cause aspiration of oral intakes, with adverse consequences.

Original languageAmerican English
Title of host publicationChemotherapy-Induced Neuropathic Pain
PublisherCRC Press
Number of pages18
ISBN (Electronic)9781439862193
ISBN (Print)9781439862186
StatePublished - 1 Jan 2012

Bibliographical note

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© 2013 by Taylor & Francis Group, LLC.


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