Over-hydration detection in brain by magnetic induction spectroscopy

César A. Gonzlez, María Pérez, Nidiyare Hevia, Fernndo Arámbula, Omar Flores, Eliot Aguilar, Ivonne Hinojosa, Leo Joskowicz, Boris Rubinsky

Research output: Contribution to journalConference articlepeer-review

9 Scopus citations


Detection and continuous monitoring of edema in the brain in early stages is useful for assessment of medical condition and treatment. We have proposed a solution in which the bulk measurements of the tissue electrical properties to detect edema or in general accumulation of fluids are made through measurement of the magnetic induction phase shift between applied and measured currents at different frequencies (Magnetic Induction Spectroscopy; MIS). Magnetic Resonant Imaging (MRI) has been characterized because its capability to detect different levels of brain tissue hydration by differences in diffusion-weighted (DW) sequences and it's involve apparent diffusion coefficient (ADC). The objective of this study was to explore the viability to use measurements of the bulk tissue electrical properties to detect edema or in general accumulation of fluids by MIS. We have induced a transitory and generalized tissue over-hydration condition in ten volunteers ingesting 1.5 to 2 liters of water in ten minutes. Basal and over-hydration conditions were monitored by MIS and MRI. Changes in the inductive phase shift at certain frequencies were consistent with changes in the brain tissue hydration level observed by DW-ADC. The results suggest that MIS has the potential to detect pathologies associated to changes in the content of fluids in brain tissue such as edema and hematomas.

Original languageAmerican English
Article number012123
JournalJournal of Physics: Conference Series
Issue number1
StatePublished - 2010
Externally publishedYes
Event14th International Conference on Electrical Bioimpedance, Held in Conjunction with the 11th Conference on Biomedical Applications of EIT, ICEBI and EIT 2010 - Gainesville, FL, United States
Duration: 4 Apr 20108 Apr 2010


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