Abstract
The oxidation of cis-[Pt(NH3)2(OAc)2] with H2O2 yields a mixture of two isomers: ctc-[Pt(NH3)2(OH)2(OAc)2] and ctc-[Pt(NH3)2(OH)(OAc)(OH)(OAc)]. Following modification with 4-phenylbutyric (PhB) anhydride, two isomers were separated and characterized; the symmetric ctc-[Pt(NH3)2(PhB)2(OAc)2] (1) and the nonsymmetric ctc-[Pt(NH3)2(PhB)(OAc)(PhB)(OAc)] (2). They differ in their log P values and despite having similar cellular uptake and similar DNA platination levels, the symmetric ctc-[Pt(NH3)2(OH)2(OAc)2] is more than 4-fold more potent than the nonsymmetric isomer in a panel of 4 cancer cell lines.
Original language | English |
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Pages (from-to) | 9475-9480 |
Number of pages | 6 |
Journal | Chemistry - A European Journal |
Volume | 26 |
Issue number | 43 |
DOIs | |
State | Published - 3 Aug 2020 |
Bibliographical note
Publisher Copyright:© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Keywords
- cytotoxicity
- diammindiacetatoplatinum(II)
- isomerization
- oxidation
- Pt anticancer agents