Oxidative metabolism of anandamide

Sumner H. Burstein*, Ronald G. Rossetti, Boris Yagen, Robert B. Zurier

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

134 Scopus citations

Abstract

In addition to the well studied hydrolytic metabolism of anandamide, a number of oxidative processes are also possible. Several routes somewhat analogous to the metabolism of free arachidonic acid have been reported. These involve mediation by various lipoxygenases and COX-2 and lead to ethanolamide analogs of the prostaglandins and HETES. The physiological significance of these products is not well understood at this time. There are also preliminary data suggesting a pathway involving oxidation of the hydroxy group of anandamide to a putative metabolite, N-arachidonyl glycine (AA-gly). This molecule displays activities in experimental models that suggest that it may play a role in some of the activities attributed to its precursor, anandamide. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)29-41
Number of pages13
JournalProstaglandins and Other Lipid Mediators
Volume61
Issue number1-2
DOIs
StatePublished - Apr 2000
Externally publishedYes

Keywords

  • Anandamide
  • Cyclooxygenase
  • Hepatocytes
  • Macrophages
  • Metabolism

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