Abstract
In addition to the well studied hydrolytic metabolism of anandamide, a number of oxidative processes are also possible. Several routes somewhat analogous to the metabolism of free arachidonic acid have been reported. These involve mediation by various lipoxygenases and COX-2 and lead to ethanolamide analogs of the prostaglandins and HETES. The physiological significance of these products is not well understood at this time. There are also preliminary data suggesting a pathway involving oxidation of the hydroxy group of anandamide to a putative metabolite, N-arachidonyl glycine (AA-gly). This molecule displays activities in experimental models that suggest that it may play a role in some of the activities attributed to its precursor, anandamide. Copyright (C) 2000 Elsevier Science Inc.
Original language | English |
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Pages (from-to) | 29-41 |
Number of pages | 13 |
Journal | Prostaglandins and Other Lipid Mediators |
Volume | 61 |
Issue number | 1-2 |
DOIs | |
State | Published - Apr 2000 |
Externally published | Yes |
Keywords
- Anandamide
- Cyclooxygenase
- Hepatocytes
- Macrophages
- Metabolism