Oxidosqualene cyclase residues that promote formation of cycloartenol, lanosterol, and parkeol

Alexander M. Khenkin; Ronny Neumann

doi:10.1002/1521-3773(20001117)39:22<4090::AID-ANIE4090>3.0.CO;2-8

Oxidosqualene cyclase residues that promote formation of cycloartenol, lanosterol, and parkeol

Alexander M. Khenkin, Ronny Neumann

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

A sterol biosynthetic intermediate from sea cucumbers is parkeol (1). By mutation of residues at two positions, the enzyme lanosterol synthase was changed enough to make parkeol as its major product, along with lanosterol (2) and lanost-24-ene-3β,9α-diol (3) as by-products.

Original language	English
Pages (from-to)	4090-4092
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	39
Issue number	22
DOIs	https://doi.org/10.1002/1521-3773(20001117)39:22<4090::AID-ANIE4090>3.0.CO;2-8
State	Published - 17 Nov 2000
Externally published	Yes

Keywords

Bioorganic chemistry
Enzyme catalysis
Mutagenesis
Steroids
Terpenoids

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10.1002/1521-3773(20001117)39:22<4090::AID-ANIE4090>3.0.CO;2-8

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abstract = "A sterol biosynthetic intermediate from sea cucumbers is parkeol (1). By mutation of residues at two positions, the enzyme lanosterol synthase was changed enough to make parkeol as its major product, along with lanosterol (2) and lanost-24-ene-3β,9α-diol (3) as by-products.",

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AU - Khenkin, Alexander M.

AU - Neumann, Ronny

PY - 2000/11/17

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N2 - A sterol biosynthetic intermediate from sea cucumbers is parkeol (1). By mutation of residues at two positions, the enzyme lanosterol synthase was changed enough to make parkeol as its major product, along with lanosterol (2) and lanost-24-ene-3β,9α-diol (3) as by-products.

AB - A sterol biosynthetic intermediate from sea cucumbers is parkeol (1). By mutation of residues at two positions, the enzyme lanosterol synthase was changed enough to make parkeol as its major product, along with lanosterol (2) and lanost-24-ene-3β,9α-diol (3) as by-products.

KW - Bioorganic chemistry

KW - Enzyme catalysis

KW - Mutagenesis

KW - Steroids

KW - Terpenoids

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Oxidosqualene cyclase residues that promote formation of cycloartenol, lanosterol, and parkeol

Abstract

Keywords

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