Oxidosqualene cyclase residues that promote formation of cycloartenol, lanosterol, and parkeol

Alexander M. Khenkin; Ronny Neumann

doi:10.1002/1521-3773(20001117)39:22<4090::AID-ANIE4090>3.0.CO;2-8

Oxidosqualene cyclase residues that promote formation of cycloartenol, lanosterol, and parkeol

Alexander M. Khenkin
, Ronny Neumann

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

A sterol biosynthetic intermediate from sea cucumbers is parkeol (1). By mutation of residues at two positions, the enzyme lanosterol synthase was changed enough to make parkeol as its major product, along with lanosterol (2) and lanost-24-ene-3β,9α-diol (3) as by-products.

Original language	English
Pages (from-to)	4090-4092
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	39
Issue number	22
DOIs	https://doi.org/10.1002/1521-3773(20001117)39:22<4090::AID-ANIE4090>3.0.CO;2-8
State	Published - 17 Nov 2000
Externally published	Yes

Keywords

Bioorganic chemistry
Enzyme catalysis
Mutagenesis
Steroids
Terpenoids

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10.1002/1521-3773(20001117)39:22<4090::AID-ANIE4090>3.0.CO;2-8

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title = "Oxidosqualene cyclase residues that promote formation of cycloartenol, lanosterol, and parkeol",

abstract = "A sterol biosynthetic intermediate from sea cucumbers is parkeol (1). By mutation of residues at two positions, the enzyme lanosterol synthase was changed enough to make parkeol as its major product, along with lanosterol (2) and lanost-24-ene-3β,9α-diol (3) as by-products.",

keywords = "Bioorganic chemistry, Enzyme catalysis, Mutagenesis, Steroids, Terpenoids",

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AU - Khenkin, Alexander M.

AU - Neumann, Ronny

PY - 2000/11/17

Y1 - 2000/11/17

N2 - A sterol biosynthetic intermediate from sea cucumbers is parkeol (1). By mutation of residues at two positions, the enzyme lanosterol synthase was changed enough to make parkeol as its major product, along with lanosterol (2) and lanost-24-ene-3β,9α-diol (3) as by-products.

AB - A sterol biosynthetic intermediate from sea cucumbers is parkeol (1). By mutation of residues at two positions, the enzyme lanosterol synthase was changed enough to make parkeol as its major product, along with lanosterol (2) and lanost-24-ene-3β,9α-diol (3) as by-products.

KW - Bioorganic chemistry

KW - Enzyme catalysis

KW - Mutagenesis

KW - Steroids

KW - Terpenoids

UR - https://www.scopus.com/pages/publications/0034680649

U2 - 10.1002/1521-3773(20001117)39:22<4090::AID-ANIE4090>3.0.CO;2-8

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AN - SCOPUS:0034680649

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 22

ER -

Oxidosqualene cyclase residues that promote formation of cycloartenol, lanosterol, and parkeol

Abstract

Keywords

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