Abstract
Cell survival depends on a continuous supply of oxygen and nutrients carried by the blood. Therefore, every cell of the body must by sufficiently close to a blood capillary to allow for efficient nutrient diffusion. A tissue cannot grow beyond ~ 1 mm in diameter before requiting new blood vessels to invade and nourish it. Tumor cells are no exception to that rule, and a vast body of evidence indeed shows that continuous blood vessel formation is obigatory for tumor growth and metastasis
| Original language | American English |
|---|---|
| Title of host publication | Angiogenesis in Health and Disease |
| Subtitle of host publication | Basic Mechanisms and Clinical Applications |
| Editors | Gabor M. Rubanyi |
| Place of Publication | Boca Raton |
| Publisher | CRC Press |
| Pages | 245-260 |
| ISBN (Electronic) | 9780429074653 |
| State | Published - 1999 |