Oxygen free radical involvement in ischemia and reperfusion injury to brain

W. Cao; J. M. Carney; A. Duchon; R. A. Floyd; M. Chevion

doi:10.1016/0304-3940(88)90132-2

Oxygen free radical involvement in ischemia and reperfusion injury to brain

W. Cao, J. M. Carney^*, A. Duchon, R. A. Floyd, M. Chevion

^*Corresponding author for this work

Institute of Biomedical Research at the Faculty of Dental Medicine

Research output: Contribution to journal › Article › peer-review

429 Scopus citations

Abstract

Evidence is presented which implicates increased oxygen free radicals during ischemia-reperfusion of gerbil brain. Salicylate, which reacts with hydroxyl free radicals to yield dihydroxybenzoic acid (DHBA), was used as an in vivo trap. Brain ischemia for at least 5 min followed by reperfusion yielded significantly increased brain DHBA. Without reperfusion or with only 2 min of ischemia and then reperfusion, the production of DHBA was not increased. Increased levels of DHBA in brain correlated with ischemia reperfusion-mediated behavioral modification of gerbils, but salicylate administration did not protect against the behavior changes.

Original language	English
Pages (from-to)	233-238
Number of pages	6
Journal	Neuroscience Letters
Volume	88
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(88)90132-2
State	Published - 26 May 1988

Keywords

Cerebral ischemia
Hydroxyl free radicals
In vivo trapping
Mongolian gerbil
Reperfusion

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10.1016/0304-3940(88)90132-2

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abstract = "Evidence is presented which implicates increased oxygen free radicals during ischemia-reperfusion of gerbil brain. Salicylate, which reacts with hydroxyl free radicals to yield dihydroxybenzoic acid (DHBA), was used as an in vivo trap. Brain ischemia for at least 5 min followed by reperfusion yielded significantly increased brain DHBA. Without reperfusion or with only 2 min of ischemia and then reperfusion, the production of DHBA was not increased. Increased levels of DHBA in brain correlated with ischemia reperfusion-mediated behavioral modification of gerbils, but salicylate administration did not protect against the behavior changes.",

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AU - Cao, W.

AU - Carney, J. M.

AU - Duchon, A.

AU - Floyd, R. A.

AU - Chevion, M.

PY - 1988/5/26

Y1 - 1988/5/26

N2 - Evidence is presented which implicates increased oxygen free radicals during ischemia-reperfusion of gerbil brain. Salicylate, which reacts with hydroxyl free radicals to yield dihydroxybenzoic acid (DHBA), was used as an in vivo trap. Brain ischemia for at least 5 min followed by reperfusion yielded significantly increased brain DHBA. Without reperfusion or with only 2 min of ischemia and then reperfusion, the production of DHBA was not increased. Increased levels of DHBA in brain correlated with ischemia reperfusion-mediated behavioral modification of gerbils, but salicylate administration did not protect against the behavior changes.

AB - Evidence is presented which implicates increased oxygen free radicals during ischemia-reperfusion of gerbil brain. Salicylate, which reacts with hydroxyl free radicals to yield dihydroxybenzoic acid (DHBA), was used as an in vivo trap. Brain ischemia for at least 5 min followed by reperfusion yielded significantly increased brain DHBA. Without reperfusion or with only 2 min of ischemia and then reperfusion, the production of DHBA was not increased. Increased levels of DHBA in brain correlated with ischemia reperfusion-mediated behavioral modification of gerbils, but salicylate administration did not protect against the behavior changes.

KW - Cerebral ischemia

KW - Hydroxyl free radicals

KW - In vivo trapping

KW - Mongolian gerbil

KW - Reperfusion

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Oxygen free radical involvement in ischemia and reperfusion injury to brain

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