p53 and the viral connection: Back into the future

Ronit Aloni-Grinstein; Meital Charni-Natan; Hilla Solomon; Varda Rotter

doi:10.3390/cancers10060178

p53 and the viral connection: Back into the future

Ronit Aloni-Grinstein, Meital Charni-Natan, Hilla Solomon, Varda Rotter^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

44 Scopus citations

Abstract

The discovery of the tumor suppressor p53, through its interactions with proteins of tumor-promoting viruses, paved the way to the understanding of p53 roles in tumor virology. Over the years, accumulating data suggest that WTp53 is involved in the viral life cycle of non-tumor-promoting viruses as well. These include the influenza virus, smallpox and vaccinia viruses, the Zika virus, West Nile virus, Japanese encephalitis virus, Human Immunodeficiency Virus Type 1, Human herpes simplex virus-1, and more. Viruses have learned to manipulate WTp53 through different strategies to improve their replication and spreading in a stage-specific, bidirectional way. While some viruses require active WTp53 for efficient viral replication, others require reduction/inhibition of WTp53 activity. A better understanding of WTp53 functionality in viral life may offer new future clinical approaches, based on WTp53 manipulation, for viral infections.

Original language	American English
Article number	178
Journal	Cancers
Volume	10
Issue number	6
DOIs	https://doi.org/10.3390/cancers10060178
State	Published - 4 Jun 2018
Externally published	Yes

Bibliographical note

Funding Information:
This publication was funded by the Center of Excellence from Flight Attendant Medical Research Institute (FAMRI) and from the Israel Science Foundation (ISF). This publication reflects the authors’ views and not necessarily those of the European Community. V.R. is the incumbent of the Norman and Helen Asher Professorial Chair Cancer Research at the Weizmann institute.

Funding Information:
Funding: This publication was funded by the Center of Excellence from Flight Attendant Medical Research Institute (FAMRI) and from the Israel Science Foundation (ISF). This publication reflects the authors’ views and not necessarily those of the European Community.

Publisher Copyright:
© 2018 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Cancer
HIV-1
HSV-1
Influenza
Papilloma
SV40
Vaccinia
Virus
Zika
p53

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cancers10060178

Cite this

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abstract = "The discovery of the tumor suppressor p53, through its interactions with proteins of tumor-promoting viruses, paved the way to the understanding of p53 roles in tumor virology. Over the years, accumulating data suggest that WTp53 is involved in the viral life cycle of non-tumor-promoting viruses as well. These include the influenza virus, smallpox and vaccinia viruses, the Zika virus, West Nile virus, Japanese encephalitis virus, Human Immunodeficiency Virus Type 1, Human herpes simplex virus-1, and more. Viruses have learned to manipulate WTp53 through different strategies to improve their replication and spreading in a stage-specific, bidirectional way. While some viruses require active WTp53 for efficient viral replication, others require reduction/inhibition of WTp53 activity. A better understanding of WTp53 functionality in viral life may offer new future clinical approaches, based on WTp53 manipulation, for viral infections.",

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note = "Funding Information: This publication was funded by the Center of Excellence from Flight Attendant Medical Research Institute (FAMRI) and from the Israel Science Foundation (ISF). This publication reflects the authors{\textquoteright} views and not necessarily those of the European Community. V.R. is the incumbent of the Norman and Helen Asher Professorial Chair Cancer Research at the Weizmann institute. Funding Information: Funding: This publication was funded by the Center of Excellence from Flight Attendant Medical Research Institute (FAMRI) and from the Israel Science Foundation (ISF). This publication reflects the authors{\textquoteright} views and not necessarily those of the European Community. Publisher Copyright: {\textcopyright} 2018 by the authors. Licensee MDPI, Basel, Switzerland.",

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p53 and the viral connection: Back into the future

Abstract

Bibliographical note

Keywords

UN SDGs

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