P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss

Ran Brosh*, Rachel Sarig, Elad Bar Natan, Alina Molchadsky, Shalom Madar, Chamutal Bornstein, Yosef Buganim, Tirosh Shapira, Naomi Goldfinger, Ralf Paus, Varda Rotter

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

The p53 tumor suppressor coordinates a multitude of cellular and organismal processes and exerts its activities mainly by activation of gene transcription. Here we describe the transcriptional activation of ectodysplasin A2 receptor (EDA2R) by p53 in a variety of cell types and tissues. We demonstrate that treatment of cancer cells with the ligand EDA-A2, known to specifically activate EDA2R, results in p53-dependent cell death. Moreover, we show that EDA2R is transactivated by p53 during chemotherapy-induced hair-loss, although its presence is not necessary for this process. These data shed new light on the role of EDA2R in exerting p53 function.

Original languageAmerican English
Pages (from-to)2473-2477
Number of pages5
JournalFEBS Letters
Volume584
Issue number11
DOIs
StatePublished - Jun 2010
Externally publishedYes

Bibliographical note

Funding Information:
Supported by a Center of Excellence grant from the Flight Attendant Medical Research Institute. V.R. is the incumbent of the Norman and Helen Asher Professorial Chair Cancer Research at the Weizmann institute.

Keywords

  • Alopecia
  • Chemotherapy-induced alopecia
  • Cyclophosphamide
  • Knockout
  • XEDAR

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