P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss

Ran Brosh; Rachel Sarig; Elad Bar Natan; Alina Molchadsky; Shalom Madar; Chamutal Bornstein; Yosef Buganim; Tirosh Shapira; Naomi Goldfinger; Ralf Paus; Varda Rotter

doi:10.1016/j.febslet.2010.04.058

P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss

Ran Brosh^*
, Rachel Sarig
, Elad Bar Natan
, Alina Molchadsky
, Shalom Madar
, Chamutal Bornstein
, Yosef Buganim
, Tirosh Shapira
, Naomi Goldfinger
, Ralf Paus
, Varda Rotter

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

The p53 tumor suppressor coordinates a multitude of cellular and organismal processes and exerts its activities mainly by activation of gene transcription. Here we describe the transcriptional activation of ectodysplasin A2 receptor (EDA2R) by p53 in a variety of cell types and tissues. We demonstrate that treatment of cancer cells with the ligand EDA-A2, known to specifically activate EDA2R, results in p53-dependent cell death. Moreover, we show that EDA2R is transactivated by p53 during chemotherapy-induced hair-loss, although its presence is not necessary for this process. These data shed new light on the role of EDA2R in exerting p53 function.

Original language	English
Pages (from-to)	2473-2477
Number of pages	5
Journal	FEBS Letters
Volume	584
Issue number	11
DOIs	https://doi.org/10.1016/j.febslet.2010.04.058
State	Published - Jun 2010
Externally published	Yes

Bibliographical note

Funding Information:
Supported by a Center of Excellence grant from the Flight Attendant Medical Research Institute. V.R. is the incumbent of the Norman and Helen Asher Professorial Chair Cancer Research at the Weizmann institute.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Alopecia
Chemotherapy-induced alopecia
Cyclophosphamide
Knockout
XEDAR

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10.1016/j.febslet.2010.04.058

Cite this

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title = "P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss",

abstract = "The p53 tumor suppressor coordinates a multitude of cellular and organismal processes and exerts its activities mainly by activation of gene transcription. Here we describe the transcriptional activation of ectodysplasin A2 receptor (EDA2R) by p53 in a variety of cell types and tissues. We demonstrate that treatment of cancer cells with the ligand EDA-A2, known to specifically activate EDA2R, results in p53-dependent cell death. Moreover, we show that EDA2R is transactivated by p53 during chemotherapy-induced hair-loss, although its presence is not necessary for this process. These data shed new light on the role of EDA2R in exerting p53 function.",

keywords = "Alopecia, Chemotherapy-induced alopecia, Cyclophosphamide, Knockout, XEDAR",

author = "Ran Brosh and Rachel Sarig and Natan, \{Elad Bar\} and Alina Molchadsky and Shalom Madar and Chamutal Bornstein and Yosef Buganim and Tirosh Shapira and Naomi Goldfinger and Ralf Paus and Varda Rotter",

note = "Funding Information: Supported by a Center of Excellence grant from the Flight Attendant Medical Research Institute. V.R. is the incumbent of the Norman and Helen Asher Professorial Chair Cancer Research at the Weizmann institute. ",

year = "2010",

month = jun,

doi = "10.1016/j.febslet.2010.04.058",

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T1 - P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss

AU - Brosh, Ran

AU - Sarig, Rachel

AU - Natan, Elad Bar

AU - Molchadsky, Alina

AU - Madar, Shalom

AU - Bornstein, Chamutal

AU - Buganim, Yosef

AU - Shapira, Tirosh

AU - Goldfinger, Naomi

AU - Paus, Ralf

AU - Rotter, Varda

N1 - Funding Information: Supported by a Center of Excellence grant from the Flight Attendant Medical Research Institute. V.R. is the incumbent of the Norman and Helen Asher Professorial Chair Cancer Research at the Weizmann institute.

PY - 2010/6

Y1 - 2010/6

N2 - The p53 tumor suppressor coordinates a multitude of cellular and organismal processes and exerts its activities mainly by activation of gene transcription. Here we describe the transcriptional activation of ectodysplasin A2 receptor (EDA2R) by p53 in a variety of cell types and tissues. We demonstrate that treatment of cancer cells with the ligand EDA-A2, known to specifically activate EDA2R, results in p53-dependent cell death. Moreover, we show that EDA2R is transactivated by p53 during chemotherapy-induced hair-loss, although its presence is not necessary for this process. These data shed new light on the role of EDA2R in exerting p53 function.

AB - The p53 tumor suppressor coordinates a multitude of cellular and organismal processes and exerts its activities mainly by activation of gene transcription. Here we describe the transcriptional activation of ectodysplasin A2 receptor (EDA2R) by p53 in a variety of cell types and tissues. We demonstrate that treatment of cancer cells with the ligand EDA-A2, known to specifically activate EDA2R, results in p53-dependent cell death. Moreover, we show that EDA2R is transactivated by p53 during chemotherapy-induced hair-loss, although its presence is not necessary for this process. These data shed new light on the role of EDA2R in exerting p53 function.

KW - Alopecia

KW - Chemotherapy-induced alopecia

KW - Cyclophosphamide

KW - Knockout

KW - XEDAR

UR - https://www.scopus.com/pages/publications/77952955114

U2 - 10.1016/j.febslet.2010.04.058

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C2 - 20434500

AN - SCOPUS:77952955114

SN - 0014-5793

VL - 584

SP - 2473

EP - 2477

JO - FEBS Letters

JF - FEBS Letters

IS - 11

ER -

P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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