Packaging of DNA origami in viral capsids

Idit Kopatz*, Ran Zalk, Yael Levi-Kalisman, Efrat Zlotkin-Rivkin, Gabriel A. Frank, Stanislav Kler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Here we show the encapsulation of 35 nm diameter, nearly-spherical, DNA origami by self-assembly of SV40-like (simian virus 40) particles. The self-assembly of this new type of nanoparticles is highly reproducible and efficient. The structure of these particles was determined by cryo-EM. The capsid forms a regular SV40 lattice of T = 7d icosahedral symmetry and the structural features of encapsulated DNA origami are fully visible. These particles are a promising biomaterial for use in various medical applications.

Original languageAmerican English
Pages (from-to)10160-10166
Number of pages7
JournalNanoscale
Volume11
Issue number21
DOIs
StatePublished - 7 Jun 2019

Bibliographical note

Publisher Copyright:
© 2019 The Royal Society of Chemistry.

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