Paclitaxel Delivery to the Brain for Glioblastoma Treatment

Muhammad AbdEl-Haq, Awanish Kumar, Fatima Ezzahra Ait Mohand, Nataly Kravchenko-Balasha, Yakir Rottenberg, Abraham J. Domb

Research output: Contribution to journalArticlepeer-review

Abstract

The development of paclitaxel-loaded polymeric nanoparticles for the treatment of brain tumors was investigated. Poly(lactide-glycolide) (PLGA) nanoparticles containing 10% w/w paclitaxel with a particle size of 216 nm were administered through intranasal and intravenous routes to male Sprague-Dawley rats at a dose of 5 mg/kg. Both routes of administration showed appreciable accumulation of paclitaxel in brain tissue, liver, and kidney without any sign of toxicity. The anti-proliferative effect of the nanoparticles on glioblastoma tumor cells was comparable to that of free paclitaxel.

Original languageAmerican English
JournalInternational Journal of Molecular Sciences
Volume24
Issue number14
DOIs
StatePublished - 21 Jul 2023

Keywords

  • brain delivery
  • glioblastoma treatment
  • intranasal (IN)
  • intravenous (IV)
  • nanoparticles (NPs)
  • paclitaxel (PTX)
  • poly(lactic-co-glycolic acid) (PLGA)

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