Paclitaxel Delivery to the Brain for Glioblastoma Treatment

Muhammad AbdEl-haq; Awanish Kumar; Fatima Ezzahra Ait Mohand; Nataly Kravchenko-Balasha; Yakir Rottenberg; Abraham J. Domb

doi:10.3390/ijms241411722

Paclitaxel Delivery to the Brain for Glioblastoma Treatment

Muhammad AbdEl-haq, Awanish Kumar, Fatima Ezzahra Ait Mohand, Nataly Kravchenko-Balasha, Yakir Rottenberg, Abraham J. Domb^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The development of paclitaxel-loaded polymeric nanoparticles for the treatment of brain tumors was investigated. Poly(lactide-glycolide) (PLGA) nanoparticles containing 10% w/w paclitaxel with a particle size of 216 nm were administered through intranasal and intravenous routes to male Sprague–Dawley rats at a dose of 5 mg/kg. Both routes of administration showed appreciable accumulation of paclitaxel in brain tissue, liver, and kidney without any sign of toxicity. The anti-proliferative effect of the nanoparticles on glioblastoma tumor cells was comparable to that of free paclitaxel.

Original language	English
Article number	11722
Journal	International Journal of Molecular Sciences
Volume	24
Issue number	14
DOIs	https://doi.org/10.3390/ijms241411722
State	Published - 21 Jul 2023

Bibliographical note

Publisher Copyright:
© 2023 by the authors.

Keywords

brain delivery
glioblastoma treatment
intranasal (IN)
intravenous (IV)
nanoparticles (NPs)
paclitaxel (PTX)
poly(lactic-co-glycolic acid) (PLGA)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijms241411722

Cite this

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title = "Paclitaxel Delivery to the Brain for Glioblastoma Treatment",

abstract = "The development of paclitaxel-loaded polymeric nanoparticles for the treatment of brain tumors was investigated. Poly(lactide-glycolide) (PLGA) nanoparticles containing 10% w/w paclitaxel with a particle size of 216 nm were administered through intranasal and intravenous routes to male Sprague–Dawley rats at a dose of 5 mg/kg. Both routes of administration showed appreciable accumulation of paclitaxel in brain tissue, liver, and kidney without any sign of toxicity. The anti-proliferative effect of the nanoparticles on glioblastoma tumor cells was comparable to that of free paclitaxel.",

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AU - Rottenberg, Yakir

AU - Domb, Abraham J.

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Paclitaxel Delivery to the Brain for Glioblastoma Treatment

Abstract

Bibliographical note

Keywords

UN SDGs

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