Pain1: A neuropathic pain QTL on mouse chromosome 15 in a C3HxC58 backcross

Marshall Devor; Amit Gilad; Michal Arbilly; Benjamin Yakir; Pnina Raber; Anne Pisanté; Ariel Darvasi

doi:10.1016/j.pain.2005.04.023

Pain1: A neuropathic pain QTL on mouse chromosome 15 in a C3HxC58 backcross

Marshall Devor, Amit Gilad, Michal Arbilly, Benjamin Yakir, Pnina Raber, Anne Pisanté, Ariel Darvasi^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

We have produced a backcross (BC) population of 267 mice from the parental strains C3H/HeN and C58/J. The mice were phenotyped for neuropathic pain using the neuroma model. Subsequently all BC mice were genotyped in a region of chromosome 15 that has been previously suggested to contain a quantitative trait locus (QTL) for this trait. We have confirmed the linkage of the QTL, named pain1, to the central region of chromosome 15. Our finding provides the necessary robustness to justify efforts towards identification of the underlying gene.

Original language	English
Pages (from-to)	289-293
Number of pages	5
Journal	Pain
Volume	116
Issue number	3
DOIs	https://doi.org/10.1016/j.pain.2005.04.023
State	Published - Aug 2005

Bibliographical note

Funding Information:
We thank Sonia delCanho and Mira Korner for their assistance. This work was supported by the Israeli Ministry of Science and Technology, the Israel Science Foundation (ISF) and the European Community's 6th Framework Program (project LSHM-CT-2004-502800 PainGenes). The manuscript reflects only the author's views. The European Community is not liable for any use that may be made of the information contained therein.

Keywords

Autotomy
Neuropathic Pain
Pain Gene
QTL

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10.1016/j.pain.2005.04.023

Cite this

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title = "Pain1: A neuropathic pain QTL on mouse chromosome 15 in a C3HxC58 backcross",

abstract = "We have produced a backcross (BC) population of 267 mice from the parental strains C3H/HeN and C58/J. The mice were phenotyped for neuropathic pain using the neuroma model. Subsequently all BC mice were genotyped in a region of chromosome 15 that has been previously suggested to contain a quantitative trait locus (QTL) for this trait. We have confirmed the linkage of the QTL, named pain1, to the central region of chromosome 15. Our finding provides the necessary robustness to justify efforts towards identification of the underlying gene.",

keywords = "Autotomy, Neuropathic Pain, Pain Gene, QTL",

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note = "Funding Information: We thank Sonia delCanho and Mira Korner for their assistance. This work was supported by the Israeli Ministry of Science and Technology, the Israel Science Foundation (ISF) and the European Community's 6th Framework Program (project LSHM-CT-2004-502800 PainGenes). The manuscript reflects only the author's views. The European Community is not liable for any use that may be made of the information contained therein.",

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AU - Gilad, Amit

AU - Arbilly, Michal

AU - Yakir, Benjamin

AU - Raber, Pnina

AU - Pisanté, Anne

AU - Darvasi, Ariel

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N2 - We have produced a backcross (BC) population of 267 mice from the parental strains C3H/HeN and C58/J. The mice were phenotyped for neuropathic pain using the neuroma model. Subsequently all BC mice were genotyped in a region of chromosome 15 that has been previously suggested to contain a quantitative trait locus (QTL) for this trait. We have confirmed the linkage of the QTL, named pain1, to the central region of chromosome 15. Our finding provides the necessary robustness to justify efforts towards identification of the underlying gene.

AB - We have produced a backcross (BC) population of 267 mice from the parental strains C3H/HeN and C58/J. The mice were phenotyped for neuropathic pain using the neuroma model. Subsequently all BC mice were genotyped in a region of chromosome 15 that has been previously suggested to contain a quantitative trait locus (QTL) for this trait. We have confirmed the linkage of the QTL, named pain1, to the central region of chromosome 15. Our finding provides the necessary robustness to justify efforts towards identification of the underlying gene.

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KW - Pain Gene

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Pain1: A neuropathic pain QTL on mouse chromosome 15 in a C3HxC58 backcross

Abstract

Bibliographical note

Keywords

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