Paired NK cell receptors controlling NK cytotoxicity

Noa Stanietsky, Ofer Mandelboim*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations


Human natural killer (NK) cells possess an arsenal of receptors programmed to regulate the NK cell functions, once encountering a target cell. In general, the activating receptors mediate cytotoxicity when engaged by their tumor specific, stress induced, virally encoded, or rarely, self ligands. Whereas, the inhibitory receptors bind self molecules, mostly MHC class I, presented on all normal and healthy nucleated cells. However, NK cells also possess numerous, highly homologous, pairs of receptors that sometimes even share the same ligands but display divergent functions. In this review we describe the NK cell repertoire of paired receptors and discuss questions regarding their function and mode of action. We focus primarily on the three PVR-binding receptors; the co-stimulatory DNAM1 and CD96 and the inhibitory TIGIT.

Original languageAmerican English
Pages (from-to)4895-4900
Number of pages6
JournalFEBS Letters
Issue number24
StatePublished - 15 Dec 2010


  • Killer activating receptors
  • Killer cell immunoglobulin-like receptors
  • Natural killer
  • Paired receptors
  • Polio virus receptor


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