Palestinian infantile visceral leishmaniasis caused by a genetic variant of Leishmania infantum belonging to a new zymodeme

Khaldoun A. Bader, Lionel F. Schnur*, Abedelmajeed Nasereddin, Francine Pratlong, Jean Pierre Dedet, Loay Shaheen, Obaida Yousef, Charles L. Greenblatt

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The parasites causing a Palestinian case of infantile visceral leishmaniasis (IVL) and those from four dogs from the Jenin District were identified serologically, biochemically and molecular biologically as Leishmania infantum, showing dogs act as a reservoir. The strain from the human case was distinct because of its unique 200-bp kDNA-polymerase chain reaction (PCR) component in its restriction fragment length polymorphism (RFLP) profile after digestion with the endonuclease RsaI, and by the electrophoretic mobility of its malate dehydrogenase (MDH 140), designating it the reference strain of a new zymodeme of L. infantum, MON-281.

Original languageEnglish
Pages (from-to)618-620
Number of pages3
JournalTropical Medicine and International Health
Volume10
Issue number6
DOIs
StatePublished - Jun 2005

Keywords

  • Isoenzyme analysis
  • Leishmania infantum
  • Palestinian authority
  • Polymerase chain reaction

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