Palladium-Catalyzed Cascade Assembly of Tricyclic Spiroethers from Diene-Alcohol Precursors

David Lankri, Yelena Mostinski, Dmitry Tsvelikhovsky*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Palladium-catalyzed carboetherification-Heck reactions to form tricyclic spiroethers, which are frequently observed as scaffold segments of various biochemical compounds, from simple diene-alcohols have been carried out in a cascade fashion. This is the first attempt to link simple alcohols with diverse, medium-sized spiroether architectures. The reported synthetic strategy is short and robust and offers rapid delivery of a broad spectrum of tricyclic spiranoid ethers.

Original languageAmerican English
Pages (from-to)9452-9463
Number of pages12
JournalJournal of Organic Chemistry
Issue number18
StatePublished - 15 Sep 2017

Bibliographical note

Funding Information:
This project was financially supported by Yissum Research Development Company of the Hebrew University of Jerusalem.

Publisher Copyright:
© 2017 American Chemical Society.


Dive into the research topics of 'Palladium-Catalyzed Cascade Assembly of Tricyclic Spiroethers from Diene-Alcohol Precursors'. Together they form a unique fingerprint.

Cite this