Abstract
Palladium-catalyzed carboetherification-Heck reactions to form tricyclic spiroethers, which are frequently observed as scaffold segments of various biochemical compounds, from simple diene-alcohols have been carried out in a cascade fashion. This is the first attempt to link simple alcohols with diverse, medium-sized spiroether architectures. The reported synthetic strategy is short and robust and offers rapid delivery of a broad spectrum of tricyclic spiranoid ethers.
| Original language | English |
|---|---|
| Pages (from-to) | 9452-9463 |
| Number of pages | 12 |
| Journal | Journal of Organic Chemistry |
| Volume | 82 |
| Issue number | 18 |
| DOIs | |
| State | Published - 15 Sep 2017 |
Bibliographical note
Funding Information:This project was financially supported by Yissum Research Development Company of the Hebrew University of Jerusalem.
Publisher Copyright:
© 2017 American Chemical Society.
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