A general and collective synthesis of medium-sized methylene lactones via controlled cyclizations of easily accessible collective precursors is described. The rapid composition of key–hydroxyalkenoic acid scaffold yields an assembly of oxocanones, oxepanones, and pyranones in a regioselective and stereodirected fashion via palladium-catalyzed cyclization. (Figure presented.).
Bibliographical noteFunding Information:
This project was financially supported by Yissum Research Development Company of the Hebrew University of Jerusalem. V. V. thanks Minerva-Stiftung for a postdoctoral fellowship.
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- hydroxyalkenoic acids