Palladium-Catalyzed Cyclization of Free Hydroxyalkenoic Acids: Regio- and Chemoselective Access to Methylene Lactones

Yelena Mostinski, Ramesh Kotikalapudi, Viviana Valerio, Riva Nataf, Dmitry Tsvelikhovsky*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

A general and collective synthesis of medium-sized methylene lactones via controlled cyclizations of easily accessible collective precursors is described. The rapid composition of key–hydroxyalkenoic acid scaffold yields an assembly of oxocanones, oxepanones, and pyranones in a regioselective and stereodirected fashion via palladium-catalyzed cyclization. (Figure presented.).

Original languageAmerican English
Pages (from-to)1164-1169
Number of pages6
JournalAdvanced Synthesis and Catalysis
Volume359
Issue number7
DOIs
StatePublished - 3 Apr 2017

Bibliographical note

Funding Information:
This project was financially supported by Yissum Research Development Company of the Hebrew University of Jerusalem. V. V. thanks Minerva-Stiftung for a postdoctoral fellowship.

Publisher Copyright:
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

  • cyclizations
  • hydroxyalkenoic acids
  • lactones
  • palladium
  • regioselectivity

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