TY - JOUR
T1 - Palmitoyl coenzyme a synthetase activation by uncomplexed ATP
AU - Rose, Gene
AU - Bar-Tana, Jacob
AU - Shapiro, Benyamin
PY - 1979/4/27
Y1 - 1979/4/27
N2 - Uncomplexed ATP, ADP, α,β-methylene ATP and adenosinetetraphosphate were shown to activate long chain fatty acyl-coenzyme A synthetase. The presence of uncomplexed nucleotides was shown: (1) to induce the palmitoyl-AMP-dependent palmitoyl-coenzyme A formation, (2) to activate the MgATP-dependent overall reaction and (3) to stabilize the synthetase against ageing denaturation. In all three cases the observed nucleotide activation was shown to be eliminated upon metal chelation.
AB - Uncomplexed ATP, ADP, α,β-methylene ATP and adenosinetetraphosphate were shown to activate long chain fatty acyl-coenzyme A synthetase. The presence of uncomplexed nucleotides was shown: (1) to induce the palmitoyl-AMP-dependent palmitoyl-coenzyme A formation, (2) to activate the MgATP-dependent overall reaction and (3) to stabilize the synthetase against ageing denaturation. In all three cases the observed nucleotide activation was shown to be eliminated upon metal chelation.
KW - Activation
KW - Palmitoyl CoA synthetase
KW - Uncomplexed ATP
UR - http://www.scopus.com/inward/record.url?scp=0018802535&partnerID=8YFLogxK
U2 - 10.1016/0005-2760(79)90179-6
DO - 10.1016/0005-2760(79)90179-6
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C2 - 454634
AN - SCOPUS:0018802535
SN - 0005-2760
VL - 573
SP - 126
EP - 135
JO - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
JF - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
IS - 1
ER -