Palmitoyl coenzyme a synthetase activation by uncomplexed ATP

Gene Rose; Jacob Bar-Tana; Benyamin Shapiro

doi:10.1016/0005-2760(79)90179-6

Palmitoyl coenzyme a synthetase activation by uncomplexed ATP

Gene Rose^*
, Jacob Bar-Tana
, Benyamin Shapiro

^*Corresponding author for this work

Braun School of Public Health and Community Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Uncomplexed ATP, ADP, α,β-methylene ATP and adenosinetetraphosphate were shown to activate long chain fatty acyl-coenzyme A synthetase. The presence of uncomplexed nucleotides was shown: (1) to induce the palmitoyl-AMP-dependent palmitoyl-coenzyme A formation, (2) to activate the MgATP-dependent overall reaction and (3) to stabilize the synthetase against ageing denaturation. In all three cases the observed nucleotide activation was shown to be eliminated upon metal chelation.

Original language	English
Pages (from-to)	126-135
Number of pages	10
Journal	Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume	573
Issue number	1
DOIs	https://doi.org/10.1016/0005-2760(79)90179-6
State	Published - 27 Apr 1979

Keywords

Activation
Palmitoyl CoA synthetase
Uncomplexed ATP

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10.1016/0005-2760(79)90179-6

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title = "Palmitoyl coenzyme a synthetase activation by uncomplexed ATP",

abstract = "Uncomplexed ATP, ADP, α,β-methylene ATP and adenosinetetraphosphate were shown to activate long chain fatty acyl-coenzyme A synthetase. The presence of uncomplexed nucleotides was shown: (1) to induce the palmitoyl-AMP-dependent palmitoyl-coenzyme A formation, (2) to activate the MgATP-dependent overall reaction and (3) to stabilize the synthetase against ageing denaturation. In all three cases the observed nucleotide activation was shown to be eliminated upon metal chelation.",

keywords = "Activation, Palmitoyl CoA synthetase, Uncomplexed ATP",

author = "Gene Rose and Jacob Bar-Tana and Benyamin Shapiro",

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T1 - Palmitoyl coenzyme a synthetase activation by uncomplexed ATP

AU - Rose, Gene

AU - Bar-Tana, Jacob

AU - Shapiro, Benyamin

PY - 1979/4/27

Y1 - 1979/4/27

N2 - Uncomplexed ATP, ADP, α,β-methylene ATP and adenosinetetraphosphate were shown to activate long chain fatty acyl-coenzyme A synthetase. The presence of uncomplexed nucleotides was shown: (1) to induce the palmitoyl-AMP-dependent palmitoyl-coenzyme A formation, (2) to activate the MgATP-dependent overall reaction and (3) to stabilize the synthetase against ageing denaturation. In all three cases the observed nucleotide activation was shown to be eliminated upon metal chelation.

AB - Uncomplexed ATP, ADP, α,β-methylene ATP and adenosinetetraphosphate were shown to activate long chain fatty acyl-coenzyme A synthetase. The presence of uncomplexed nucleotides was shown: (1) to induce the palmitoyl-AMP-dependent palmitoyl-coenzyme A formation, (2) to activate the MgATP-dependent overall reaction and (3) to stabilize the synthetase against ageing denaturation. In all three cases the observed nucleotide activation was shown to be eliminated upon metal chelation.

KW - Activation

KW - Palmitoyl CoA synthetase

KW - Uncomplexed ATP

UR - https://www.scopus.com/pages/publications/0018802535

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JF - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

IS - 1

ER -

Palmitoyl coenzyme a synthetase activation by uncomplexed ATP

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