Pan-drug resistant Providencia rettgeri contributing to a fatal case of COVID-19

Patrick M. McGann; Matthew R. Geringer; Lindsey R. Hall; Francois Lebreton; Elizabeth Markelz; Yoon I. Kwak; Sheila Johnson; Ana C. Ong; Aubrey Powell; Tsigereda Tekle; Yehudit Bergman; Patricia J. Simner; Jason W. Bennett; Robert J. Cybulski; Brian K. White

doi:10.1099/jmm.0.001406

Pan-drug resistant Providencia rettgeri contributing to a fatal case of COVID-19

Patrick M. McGann^*, Matthew R. Geringer, Lindsey R. Hall, Francois Lebreton, Elizabeth Markelz, Yoon I. Kwak, Sheila Johnson, Ana C. Ong, Aubrey Powell, Tsigereda Tekle, Yehudit Bergman, Patricia J. Simner, Jason W. Bennett, Robert J. Cybulski, Brian K. White^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Following prolonged hospitalization that included broad-spectrum antibiotic exposure, a strain of Providencia rettgeri was cultured from the blood of a patient undergoing extracorporeal membrane oxygenation treatment for hypoxic respiratory failure due to COVID-19. The strain was resistant to all antimicrobials tested including the novel siderophore cephalosporin, cefiderocol. Whole genome sequencing detected ten antimicrobial resistance genes, including the metallo-β-lactamase blaNDM-1, the extended-spectrum β-lactamase blaPER-1, and the rare 16S methyltransferase rmtB2.

Original language	English
Article number	001406
Journal	Journal of Medical Microbiology
Volume	70
Issue number	8
DOIs	https://doi.org/10.1099/jmm.0.001406
State	Published - 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 The Authors.

Keywords

COVID-19
Cefiderocol resistance
NDM carbapenemase
Providencia rettgeri

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1099/jmm.0.001406

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McGann, P. M., Geringer, M. R., Hall, L. R., Lebreton, F., Markelz, E., Kwak, Y. I., Johnson, S., Ong, A. C., Powell, A., Tekle, T., Bergman, Y., Simner, P. J., Bennett, J. W., Cybulski, R. J., & White, B. K. (2021). Pan-drug resistant Providencia rettgeri contributing to a fatal case of COVID-19. Journal of Medical Microbiology, 70(8), Article 001406. https://doi.org/10.1099/jmm.0.001406

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abstract = "Following prolonged hospitalization that included broad-spectrum antibiotic exposure, a strain of Providencia rettgeri was cultured from the blood of a patient undergoing extracorporeal membrane oxygenation treatment for hypoxic respiratory failure due to COVID-19. The strain was resistant to all antimicrobials tested including the novel siderophore cephalosporin, cefiderocol. Whole genome sequencing detected ten antimicrobial resistance genes, including the metallo-β-lactamase blaNDM-1, the extended-spectrum β-lactamase blaPER-1, and the rare 16S methyltransferase rmtB2.",

keywords = "COVID-19, Cefiderocol resistance, NDM carbapenemase, Providencia rettgeri",

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doi = "10.1099/jmm.0.001406",

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AU - Geringer, Matthew R.

AU - Hall, Lindsey R.

AU - Lebreton, Francois

AU - Markelz, Elizabeth

AU - Kwak, Yoon I.

AU - Johnson, Sheila

AU - Ong, Ana C.

AU - Powell, Aubrey

AU - Tekle, Tsigereda

AU - Bergman, Yehudit

AU - Simner, Patricia J.

AU - Bennett, Jason W.

AU - Cybulski, Robert J.

AU - White, Brian K.

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AB - Following prolonged hospitalization that included broad-spectrum antibiotic exposure, a strain of Providencia rettgeri was cultured from the blood of a patient undergoing extracorporeal membrane oxygenation treatment for hypoxic respiratory failure due to COVID-19. The strain was resistant to all antimicrobials tested including the novel siderophore cephalosporin, cefiderocol. Whole genome sequencing detected ten antimicrobial resistance genes, including the metallo-β-lactamase blaNDM-1, the extended-spectrum β-lactamase blaPER-1, and the rare 16S methyltransferase rmtB2.

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KW - Providencia rettgeri

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Pan-drug resistant Providencia rettgeri contributing to a fatal case of COVID-19

Abstract

Bibliographical note

Keywords

UN SDGs

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