Pan-drug resistant Providencia rettgeri contributing to a fatal case of COVID-19

Patrick M. McGann*, Matthew R. Geringer, Lindsey R. Hall, Francois Lebreton, Elizabeth Markelz, Yoon I. Kwak, Sheila Johnson, Ana C. Ong, Aubrey Powell, Tsigereda Tekle, Yehudit Bergman, Patricia J. Simner, Jason W. Bennett, Robert J. Cybulski, Brian K. White*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Following prolonged hospitalization that included broad-spectrum antibiotic exposure, a strain of Providencia rettgeri was cultured from the blood of a patient undergoing extracorporeal membrane oxygenation treatment for hypoxic respiratory failure due to COVID-19. The strain was resistant to all antimicrobials tested including the novel siderophore cephalosporin, cefiderocol. Whole genome sequencing detected ten antimicrobial resistance genes, including the metallo-β-lactamase blaNDM-1, the extended-spectrum β-lactamase blaPER-1, and the rare 16S methyltransferase rmtB2.

Original languageAmerican English
Article number001406
JournalJournal of Medical Microbiology
Volume70
Issue number8
DOIs
StatePublished - 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2021 The Authors.

Keywords

  • COVID-19
  • Cefiderocol resistance
  • NDM carbapenemase
  • Providencia rettgeri

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