Pancreatitis following hepatitis A vaccination.

Y. S. Haviv*, M. Sharkia, E. Galun, R. Safadi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


We describe a 23-year-old male patient who presented with epigastric abdominal pain, 8 days following vaccination with inactivated hepatitis A virus (Haverix(R)). Clinical and laboratory data confirmed the diagnosis of pancreatitis. Repeat polymerase chain reaction (PCR) for hepatitis A replication was negative. A comprehensive evaluation ruled out other etiologies for pancreatitis. IgM Hepatitis A antibodies did not develop even after 3 months. Pancreatitis following Hepatitis A is a well-known complication of the viremia, but the exact mechanism is controversial. We suggest that the pancreatitis may have been a cellular immunlogical reaction to one of the antigens of hepatitis A virus vaccine, or it might have been caused by the release of mediators of anaphylaxis such as histamine and leucotriens, induced by HAV antigens, resulting in pancreatitis without development of humoral immunization.

Original languageAmerican English
Pages (from-to)229-230
Number of pages2
JournalEuropean Journal of Medical Research
Issue number5
StatePublished - 23 May 2000
Externally publishedYes


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