Pandangolide 1a, a metabolite of the sponge-associated fungus Cladosporium sp., and the absolute stereochemistry of pandangolide 1 and iso-cladospolide B

Shiri Gesner, Naama Cohen, Micha Ilan, Oded Yarden, Shmuel Carmeli*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Fractionation of the ethyl acetate extract of a Cladosporium sp., isolated from the Red Sea sponge Niphates rowi, yielded a new hexaketide, pandangolide 1a (1), together with its known diastereomer pandangolide 1 (2) and the known iso-cladospolide B (3). The structures of the compounds were determined by 1D and 2D NMR techniques and mass spectrometric data. The absolute configurations of the stereocenters in these compounds were determined by Riguera's method and circular dichroism.

Original languageAmerican English
Pages (from-to)1350-1353
Number of pages4
JournalJournal of Natural Products
Volume68
Issue number9
DOIs
StatePublished - Sep 2005

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