Paradigm shift in early detection: Lung cancer screening to comprehensive CT screening

James L. Mulshine; Bruce Pyenson; Cheryl Healton; Carolyn Aldige; Riccardo S. Avila; Torsten Blum; Matthew Cham; Harry J. de Koning; Sean B. Fain; John K. Field; Raja Flores; Maryellen L. Giger; Ilya Gipp; Frederic W. Grannis; Jan Willem C. Gratama; Ella A. Kazerooni; Karen Kelly; Harriet L. Lancaster; Luis Montuenga; Kyle J. Myers; Morteza Naghavi; Raymond Osarogiagbon; Ugo Pastorino; Anthony P. Reeves; Albert Rizzo; Sheila Ross; Victoria Schneider; Luis M. Seijo; Dorith Shaham; Mario Silva; Robert Smith; Emanuela Taioli; Kevin ten Haaf; Carlijn M. van der Aalst; Lucia Viola; Jens Vogel-Claussen; Anna N.H. Walstra; Ning Wu; Pan Chyr Yang; Rowena Yip; David F. Yankelevitz; Claudia I. Henschke; Matthijs Oudkerk

doi:10.1016/j.ejca.2025.115264

Paradigm shift in early detection: Lung cancer screening to comprehensive CT screening

James L. Mulshine^*, Bruce Pyenson, Cheryl Healton, Carolyn Aldige, Riccardo S. Avila, Torsten Blum, Matthew Cham, Harry J. de Koning, Sean B. Fain, John K. Field, Raja Flores, Maryellen L. Giger, Ilya Gipp, Frederic W. Grannis, Jan Willem C. Gratama, Ella A. Kazerooni, Karen Kelly, Harriet L. Lancaster, Luis Montuenga, Kyle J. MyersMorteza Naghavi, Raymond Osarogiagbon, Ugo Pastorino, Anthony P. Reeves, Albert Rizzo, Sheila Ross, Victoria Schneider, Luis M. Seijo, Dorith Shaham, Mario Silva, Robert Smith, Emanuela Taioli, Kevin ten Haaf, Carlijn M. van der Aalst, Lucia Viola, Jens Vogel-Claussen, Anna N.H. Walstra, Ning Wu, Pan Chyr Yang, Rowena Yip, David F. Yankelevitz, Claudia I. Henschke, Matthijs Oudkerk

^*Corresponding author for this work

Center for Medical Education

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Large-scale lung cancer screening implementation combined with improvements in early detection techniques for three major tobacco-related diseases presents a rare opportunity to markedly improve population health outcomes for millions of people. Chest CT enables routine detection of early lung cancer as well as characterizing coronary calcium and detecting early emphysema in the course of lung cancer screening. Integrated preventive care centered on comprehensive chest CT screening has the potential to bring large benefits across co-morbid diseases with a common etiology. The current one-disease/ silo paradigm of medical practice is an obstacle to maximizing chest CT screening's benefits. The large potential for improved health outcomes across the world demands careful public health, quality assurance, and health policy considerations. A systematic analysis of imaging and health data from ongoing chest CT screening could accelerate this paradigm shift through sustained optimization of screening detection, quantitation and management for the three most lethal tobacco-related co-morbidities. To coordinate this effort to advance progress with implementing the full benefit of comprehensive chest CT screening, a new multi- disciplinary professional and advocacy consortium has been developed to foster collaboration to realize the future of multi-disease chest CT screening.

Original language	English
Article number	115264
Journal	European Journal of Cancer
Volume	218
DOIs	https://doi.org/10.1016/j.ejca.2025.115264
State	Published - 11 Mar 2025

Bibliographical note

Publisher Copyright:
© 2025

Keywords

Chest CT scan
Chronic obstructive pulmonary disease
Coronary artery disease
Emphysema
Lung cancer
Lung cancer screening
Quantitative imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ejca.2025.115264

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Mulshine, J. L., Pyenson, B., Healton, C., Aldige, C., Avila, R. S., Blum, T., Cham, M., de Koning, H. J., Fain, S. B., Field, J. K., Flores, R., Giger, M. L., Gipp, I., Grannis, F. W., Gratama, J. W. C., Kazerooni, E. A., Kelly, K., Lancaster, H. L., Montuenga, L., ... Oudkerk, M. (2025). Paradigm shift in early detection: Lung cancer screening to comprehensive CT screening. European Journal of Cancer, 218, Article 115264. https://doi.org/10.1016/j.ejca.2025.115264

@article{aeac081704ef4604bfd2cc22e3f26831,

title = "Paradigm shift in early detection: Lung cancer screening to comprehensive CT screening",

abstract = "Large-scale lung cancer screening implementation combined with improvements in early detection techniques for three major tobacco-related diseases presents a rare opportunity to markedly improve population health outcomes for millions of people. Chest CT enables routine detection of early lung cancer as well as characterizing coronary calcium and detecting early emphysema in the course of lung cancer screening. Integrated preventive care centered on comprehensive chest CT screening has the potential to bring large benefits across co-morbid diseases with a common etiology. The current one-disease/ silo paradigm of medical practice is an obstacle to maximizing chest CT screening's benefits. The large potential for improved health outcomes across the world demands careful public health, quality assurance, and health policy considerations. A systematic analysis of imaging and health data from ongoing chest CT screening could accelerate this paradigm shift through sustained optimization of screening detection, quantitation and management for the three most lethal tobacco-related co-morbidities. To coordinate this effort to advance progress with implementing the full benefit of comprehensive chest CT screening, a new multi- disciplinary professional and advocacy consortium has been developed to foster collaboration to realize the future of multi-disease chest CT screening.",

keywords = "Chest CT scan, Chronic obstructive pulmonary disease, Coronary artery disease, Emphysema, Lung cancer, Lung cancer screening, Quantitative imaging",

author = "Mulshine, {James L.} and Bruce Pyenson and Cheryl Healton and Carolyn Aldige and Avila, {Riccardo S.} and Torsten Blum and Matthew Cham and {de Koning}, {Harry J.} and Fain, {Sean B.} and Field, {John K.} and Raja Flores and Giger, {Maryellen L.} and Ilya Gipp and Grannis, {Frederic W.} and Gratama, {Jan Willem C.} and Kazerooni, {Ella A.} and Karen Kelly and Lancaster, {Harriet L.} and Luis Montuenga and Myers, {Kyle J.} and Morteza Naghavi and Raymond Osarogiagbon and Ugo Pastorino and Reeves, {Anthony P.} and Albert Rizzo and Sheila Ross and Victoria Schneider and Seijo, {Luis M.} and Dorith Shaham and Mario Silva and Robert Smith and Emanuela Taioli and {ten Haaf}, Kevin and {van der Aalst}, {Carlijn M.} and Lucia Viola and Jens Vogel-Claussen and Walstra, {Anna N.H.} and Ning Wu and Yang, {Pan Chyr} and Rowena Yip and Yankelevitz, {David F.} and Henschke, {Claudia I.} and Matthijs Oudkerk",

note = "Publisher Copyright: {\textcopyright} 2025",

year = "2025",

month = mar,

day = "11",

doi = "10.1016/j.ejca.2025.115264",

language = "אנגלית",

volume = "218",

journal = "European Journal of Cancer",

issn = "0959-8049",

publisher = "Elsevier Ltd.",

}

Mulshine, JL, Pyenson, B, Healton, C, Aldige, C, Avila, RS, Blum, T, Cham, M, de Koning, HJ, Fain, SB, Field, JK, Flores, R, Giger, ML, Gipp, I, Grannis, FW, Gratama, JWC, Kazerooni, EA, Kelly, K, Lancaster, HL, Montuenga, L, Myers, KJ, Naghavi, M, Osarogiagbon, R, Pastorino, U, Reeves, AP, Rizzo, A, Ross, S, Schneider, V, Seijo, LM, Shaham, D, Silva, M, Smith, R, Taioli, E, ten Haaf, K, van der Aalst, CM, Viola, L, Vogel-Claussen, J, Walstra, ANH, Wu, N, Yang, PC, Yip, R, Yankelevitz, DF, Henschke, CI & Oudkerk, M 2025, 'Paradigm shift in early detection: Lung cancer screening to comprehensive CT screening', European Journal of Cancer, vol. 218, 115264. https://doi.org/10.1016/j.ejca.2025.115264

TY - JOUR

T1 - Paradigm shift in early detection

T2 - Lung cancer screening to comprehensive CT screening

AU - Mulshine, James L.

AU - Pyenson, Bruce

AU - Healton, Cheryl

AU - Aldige, Carolyn

AU - Avila, Riccardo S.

AU - Blum, Torsten

AU - Cham, Matthew

AU - de Koning, Harry J.

AU - Fain, Sean B.

AU - Field, John K.

AU - Flores, Raja

AU - Giger, Maryellen L.

AU - Gipp, Ilya

AU - Grannis, Frederic W.

AU - Gratama, Jan Willem C.

AU - Kazerooni, Ella A.

AU - Kelly, Karen

AU - Lancaster, Harriet L.

AU - Montuenga, Luis

AU - Myers, Kyle J.

AU - Naghavi, Morteza

AU - Osarogiagbon, Raymond

AU - Pastorino, Ugo

AU - Reeves, Anthony P.

AU - Rizzo, Albert

AU - Ross, Sheila

AU - Schneider, Victoria

AU - Seijo, Luis M.

AU - Shaham, Dorith

AU - Silva, Mario

AU - Smith, Robert

AU - Taioli, Emanuela

AU - ten Haaf, Kevin

AU - van der Aalst, Carlijn M.

AU - Viola, Lucia

AU - Vogel-Claussen, Jens

AU - Walstra, Anna N.H.

AU - Wu, Ning

AU - Yang, Pan Chyr

AU - Yip, Rowena

AU - Yankelevitz, David F.

AU - Henschke, Claudia I.

AU - Oudkerk, Matthijs

PY - 2025/3/11

Y1 - 2025/3/11

N2 - Large-scale lung cancer screening implementation combined with improvements in early detection techniques for three major tobacco-related diseases presents a rare opportunity to markedly improve population health outcomes for millions of people. Chest CT enables routine detection of early lung cancer as well as characterizing coronary calcium and detecting early emphysema in the course of lung cancer screening. Integrated preventive care centered on comprehensive chest CT screening has the potential to bring large benefits across co-morbid diseases with a common etiology. The current one-disease/ silo paradigm of medical practice is an obstacle to maximizing chest CT screening's benefits. The large potential for improved health outcomes across the world demands careful public health, quality assurance, and health policy considerations. A systematic analysis of imaging and health data from ongoing chest CT screening could accelerate this paradigm shift through sustained optimization of screening detection, quantitation and management for the three most lethal tobacco-related co-morbidities. To coordinate this effort to advance progress with implementing the full benefit of comprehensive chest CT screening, a new multi- disciplinary professional and advocacy consortium has been developed to foster collaboration to realize the future of multi-disease chest CT screening.

AB - Large-scale lung cancer screening implementation combined with improvements in early detection techniques for three major tobacco-related diseases presents a rare opportunity to markedly improve population health outcomes for millions of people. Chest CT enables routine detection of early lung cancer as well as characterizing coronary calcium and detecting early emphysema in the course of lung cancer screening. Integrated preventive care centered on comprehensive chest CT screening has the potential to bring large benefits across co-morbid diseases with a common etiology. The current one-disease/ silo paradigm of medical practice is an obstacle to maximizing chest CT screening's benefits. The large potential for improved health outcomes across the world demands careful public health, quality assurance, and health policy considerations. A systematic analysis of imaging and health data from ongoing chest CT screening could accelerate this paradigm shift through sustained optimization of screening detection, quantitation and management for the three most lethal tobacco-related co-morbidities. To coordinate this effort to advance progress with implementing the full benefit of comprehensive chest CT screening, a new multi- disciplinary professional and advocacy consortium has been developed to foster collaboration to realize the future of multi-disease chest CT screening.

KW - Chest CT scan

KW - Chronic obstructive pulmonary disease

KW - Coronary artery disease

KW - Emphysema

KW - Lung cancer

KW - Lung cancer screening

KW - Quantitative imaging

UR - http://www.scopus.com/inward/record.url?scp=85216639249&partnerID=8YFLogxK

U2 - 10.1016/j.ejca.2025.115264

DO - 10.1016/j.ejca.2025.115264

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C2 - 39904127

AN - SCOPUS:85216639249

SN - 0959-8049

VL - 218

JO - European Journal of Cancer

JF - European Journal of Cancer

M1 - 115264

ER -

Paradigm shift in early detection: Lung cancer screening to comprehensive CT screening

Abstract

Bibliographical note

Keywords

UN SDGs

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