Parallel computation enables precise description of Ca²⁺ distribution in nerve terminals

Parallel computation employing a domain decomposition method was used to calculate precisely without approximations the spatio-temporal distribution of Ca²⁺ in nerve terminals. The results showed, contrary to expectations, that for equal admitted Ca²⁺ currents at low (one channel open) and high (four channels open) depolarization, the average Ca²⁺ concentration at the release area is higher at the low depolarization. These calculations provide additional support for the Ca²⁺-voltage hypothesis for neurotransmitter release.