TY - JOUR
T1 - Pardachirus marmoratus (Red Sea flatfish) secretion and its isolated toxic fraction pardaxin
T2 - The relationship between hemolysis and ATPase inhibition
AU - Primor, Naftali
AU - Lazarovici, Philip
PY - 1981
Y1 - 1981
N2 - The ichthyocrinotoxic secretion of the Red Sea flatfish Pardachirus marmoratus and paradaxin, a polypeptide isolated from this secretion, were toxic when injected i.v. into rats. Pardaxin inhibits [Na+, K+] ATPase (Primor et al., 1980) but enhances esterase activity. Pardaxin caused hemolysis in dog red blood cells which lack [Na+, K+] ATPase. It is concluded that pardaxin induced hemolysis is not caused by [Na+, K+] ATPase inhibition.
AB - The ichthyocrinotoxic secretion of the Red Sea flatfish Pardachirus marmoratus and paradaxin, a polypeptide isolated from this secretion, were toxic when injected i.v. into rats. Pardaxin inhibits [Na+, K+] ATPase (Primor et al., 1980) but enhances esterase activity. Pardaxin caused hemolysis in dog red blood cells which lack [Na+, K+] ATPase. It is concluded that pardaxin induced hemolysis is not caused by [Na+, K+] ATPase inhibition.
UR - http://www.scopus.com/inward/record.url?scp=0019488265&partnerID=8YFLogxK
U2 - 10.1016/0041-0101(81)90018-0
DO - 10.1016/0041-0101(81)90018-0
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C2 - 6277043
AN - SCOPUS:0019488265
SN - 0041-0101
VL - 19
SP - 573
EP - 578
JO - Toxicon
JF - Toxicon
IS - 4
ER -