Pardachirus marmoratus (Red Sea flatfish) secretion and its isolated toxic fraction pardaxin: The relationship between hemolysis and ATPase inhibition

Naftali Primor; Philip Lazarovici

doi:10.1016/0041-0101(81)90018-0

Pardachirus marmoratus (Red Sea flatfish) secretion and its isolated toxic fraction pardaxin: The relationship between hemolysis and ATPase inhibition

Naftali Primor^*
, Philip Lazarovici

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The ichthyocrinotoxic secretion of the Red Sea flatfish Pardachirus marmoratus and paradaxin, a polypeptide isolated from this secretion, were toxic when injected i.v. into rats. Pardaxin inhibits [Na⁺, K⁺] ATPase (Primor et al., 1980) but enhances esterase activity. Pardaxin caused hemolysis in dog red blood cells which lack [Na⁺, K⁺] ATPase. It is concluded that pardaxin induced hemolysis is not caused by [Na⁺, K⁺] ATPase inhibition.

Original language	English
Pages (from-to)	573-578
Number of pages	6
Journal	Toxicon
Volume	19
Issue number	4
DOIs	https://doi.org/10.1016/0041-0101(81)90018-0
State	Published - 1981
Externally published	Yes

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title = "Pardachirus marmoratus (Red Sea flatfish) secretion and its isolated toxic fraction pardaxin: The relationship between hemolysis and ATPase inhibition",

abstract = "The ichthyocrinotoxic secretion of the Red Sea flatfish Pardachirus marmoratus and paradaxin, a polypeptide isolated from this secretion, were toxic when injected i.v. into rats. Pardaxin inhibits [Na+, K+] ATPase (Primor et al., 1980) but enhances esterase activity. Pardaxin caused hemolysis in dog red blood cells which lack [Na+, K+] ATPase. It is concluded that pardaxin induced hemolysis is not caused by [Na+, K+] ATPase inhibition.",

author = "Naftali Primor and Philip Lazarovici",

year = "1981",

doi = "10.1016/0041-0101(81)90018-0",

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AU - Lazarovici, Philip

PY - 1981

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AB - The ichthyocrinotoxic secretion of the Red Sea flatfish Pardachirus marmoratus and paradaxin, a polypeptide isolated from this secretion, were toxic when injected i.v. into rats. Pardaxin inhibits [Na+, K+] ATPase (Primor et al., 1980) but enhances esterase activity. Pardaxin caused hemolysis in dog red blood cells which lack [Na+, K+] ATPase. It is concluded that pardaxin induced hemolysis is not caused by [Na+, K+] ATPase inhibition.

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Pardachirus marmoratus (Red Sea flatfish) secretion and its isolated toxic fraction pardaxin: The relationship between hemolysis and ATPase inhibition

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