Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C)

on behalf of the International Childhood Cancer Cohort Consortium

doi:10.1002/ijc.32388

Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C)

on behalf of the International Childhood Cancer Cohort Consortium

Braun School of Public Health and Community Medicine

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Parental occupational exposures to pesticides, animals and organic dust have been associated with an increased risk of childhood cancer based mostly on case–control studies. We prospectively evaluated parental occupational exposures and risk of childhood leukemia and central nervous system (CNS) tumors in the International Childhood Cancer Cohort Consortium. We pooled data on 329,658 participants from birth cohorts in five countries (Australia, Denmark, Israel, Norway and United Kingdom). Parental occupational exposures during pregnancy were estimated by linking International Standard Classification of Occupations-1988 job codes to the ALOHA+ job exposure matrix. Risk of childhood (<15 years) acute lymphoblastic leukemia (ALL; n = 129), acute myeloid leukemia (AML; n = 31) and CNS tumors (n = 158) was estimated using Cox proportional hazards models to generate hazard ratios (HR) and 95% confidence intervals (CI). Paternal exposures to pesticides and animals were associated with increased risk of childhood AML (herbicides HR = 3.22, 95% CI = 0.97–10.68; insecticides HR = 2.86, 95% CI = 0.99–8.23; animals HR = 3.89, 95% CI = 1.18–12.90), but not ALL or CNS tumors. Paternal exposure to organic dust was positively associated with AML (HR = 2.38 95% CI = 1.12–5.07), inversely associated with ALL (HR = 0.55, 95% CI = 0.31–0.99) and not associated with CNS tumors. Low exposure prevalence precluded evaluation of maternal pesticide and animal exposures; we observed no significant associations with organic dust exposure. This first prospective analysis of pooled birth cohorts and parental occupational exposures provides evidence for paternal agricultural exposures as childhood AML risk factors. The different risks for childhood ALL associated with maternal and paternal organic dust exposures should be investigated further.

Original language	American English
Pages (from-to)	943-952
Number of pages	10
Journal	International Journal of Cancer
Volume	146
Issue number	4
DOIs	https://doi.org/10.1002/ijc.32388
State	Published - 15 Feb 2020

Bibliographical note

Funding Information:
We would like to thank all cohorts from the I4C that participated in our study and Gary S. Phillips (Ohio State University) for help with data harmonization. The ALSPAC cohort is extremely grateful to all the families who took part in our study, the midwives for their help in recruiting them, and the whole ALSPAC team, which includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists and nurses. Danish cancer cases were ascertained by the Danish Childhood Cancer Registry (Steering Committee: Catherine Rechnitzer, Peter Skov Wehner, Steen Rosthøj and Henrik Schrøder).

Publisher Copyright:
© 2019 UICC

Keywords

agricultural exposures
animals
childhood brain tumors
childhood cancer
childhood leukemia
organic dust
parental occupation
pesticides

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/ijc.32388

Fingerprint

Dive into the research topics of 'Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C)'. Together they form a unique fingerprint.

Cite this

@article{405ac426d2b24c43963cfc4d93cfa838,

title = "Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C)",

abstract = "Parental occupational exposures to pesticides, animals and organic dust have been associated with an increased risk of childhood cancer based mostly on case–control studies. We prospectively evaluated parental occupational exposures and risk of childhood leukemia and central nervous system (CNS) tumors in the International Childhood Cancer Cohort Consortium. We pooled data on 329,658 participants from birth cohorts in five countries (Australia, Denmark, Israel, Norway and United Kingdom). Parental occupational exposures during pregnancy were estimated by linking International Standard Classification of Occupations-1988 job codes to the ALOHA+ job exposure matrix. Risk of childhood (<15 years) acute lymphoblastic leukemia (ALL; n = 129), acute myeloid leukemia (AML; n = 31) and CNS tumors (n = 158) was estimated using Cox proportional hazards models to generate hazard ratios (HR) and 95% confidence intervals (CI). Paternal exposures to pesticides and animals were associated with increased risk of childhood AML (herbicides HR = 3.22, 95% CI = 0.97–10.68; insecticides HR = 2.86, 95% CI = 0.99–8.23; animals HR = 3.89, 95% CI = 1.18–12.90), but not ALL or CNS tumors. Paternal exposure to organic dust was positively associated with AML (HR = 2.38 95% CI = 1.12–5.07), inversely associated with ALL (HR = 0.55, 95% CI = 0.31–0.99) and not associated with CNS tumors. Low exposure prevalence precluded evaluation of maternal pesticide and animal exposures; we observed no significant associations with organic dust exposure. This first prospective analysis of pooled birth cohorts and parental occupational exposures provides evidence for paternal agricultural exposures as childhood AML risk factors. The different risks for childhood ALL associated with maternal and paternal organic dust exposures should be investigated further.",

keywords = "agricultural exposures, animals, childhood brain tumors, childhood cancer, childhood leukemia, organic dust, parental occupation, pesticides",

author = "{on behalf of the International Childhood Cancer Cohort Consortium} and Patel, {Deven M.} and Jones, {Rena R.} and Booth, {Benjamin J.} and Olsson, {Ann C.} and Hans Kromhout and Kurt Straif and Roel Vermeulen and Gabriella Tikellis and Ora Paltiel and Jean Golding and Kate Northstone and Camilla Stoltenberg and H{\aa}berg, {Siri E.} and Joachim Sch{\"u}z and Friesen, {Melissa C.} and Ponsonby, {Anne Louise} and Stanley Lemeshow and Linet, {Martha S.} and Per Magnus and J{\o}rn Olsen and Olsen, {Sjurdur F.} and Terence Dwyer and Stayner, {Leslie T.} and Ward, {Mary H.}",

note = "Funding Information: We would like to thank all cohorts from the I4C that participated in our study and Gary S. Phillips (Ohio State University) for help with data harmonization. The ALSPAC cohort is extremely grateful to all the families who took part in our study, the midwives for their help in recruiting them, and the whole ALSPAC team, which includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists and nurses. Danish cancer cases were ascertained by the Danish Childhood Cancer Registry (Steering Committee: Catherine Rechnitzer, Peter Skov Wehner, Steen Rosth{\o}j and Henrik Schr{\o}der). Publisher Copyright: {\textcopyright} 2019 UICC",

year = "2020",

month = feb,

day = "15",

doi = "10.1002/ijc.32388",

language = "American English",

volume = "146",

pages = "943--952",

journal = "International Journal of Cancer",

issn = "0020-7136",

publisher = "Wiley-Liss Inc.",

number = "4",

}

on behalf of the International Childhood Cancer Cohort Consortium 2020, 'Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C)', International Journal of Cancer, vol. 146, no. 4, pp. 943-952. https://doi.org/10.1002/ijc.32388

Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C). / on behalf of the International Childhood Cancer Cohort Consortium.
In: International Journal of Cancer, Vol. 146, No. 4, 15.02.2020, p. 943-952.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors

T2 - Findings from the International Childhood Cancer Cohort Consortium (I4C)

AU - on behalf of the International Childhood Cancer Cohort Consortium

AU - Patel, Deven M.

AU - Jones, Rena R.

AU - Booth, Benjamin J.

AU - Olsson, Ann C.

AU - Kromhout, Hans

AU - Straif, Kurt

AU - Vermeulen, Roel

AU - Tikellis, Gabriella

AU - Paltiel, Ora

AU - Golding, Jean

AU - Northstone, Kate

AU - Stoltenberg, Camilla

AU - Håberg, Siri E.

AU - Schüz, Joachim

AU - Friesen, Melissa C.

AU - Ponsonby, Anne Louise

AU - Lemeshow, Stanley

AU - Linet, Martha S.

AU - Magnus, Per

AU - Olsen, Jørn

AU - Olsen, Sjurdur F.

AU - Dwyer, Terence

AU - Stayner, Leslie T.

AU - Ward, Mary H.

N1 - Funding Information: We would like to thank all cohorts from the I4C that participated in our study and Gary S. Phillips (Ohio State University) for help with data harmonization. The ALSPAC cohort is extremely grateful to all the families who took part in our study, the midwives for their help in recruiting them, and the whole ALSPAC team, which includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists and nurses. Danish cancer cases were ascertained by the Danish Childhood Cancer Registry (Steering Committee: Catherine Rechnitzer, Peter Skov Wehner, Steen Rosthøj and Henrik Schrøder). Publisher Copyright: © 2019 UICC

PY - 2020/2/15

Y1 - 2020/2/15

N2 - Parental occupational exposures to pesticides, animals and organic dust have been associated with an increased risk of childhood cancer based mostly on case–control studies. We prospectively evaluated parental occupational exposures and risk of childhood leukemia and central nervous system (CNS) tumors in the International Childhood Cancer Cohort Consortium. We pooled data on 329,658 participants from birth cohorts in five countries (Australia, Denmark, Israel, Norway and United Kingdom). Parental occupational exposures during pregnancy were estimated by linking International Standard Classification of Occupations-1988 job codes to the ALOHA+ job exposure matrix. Risk of childhood (<15 years) acute lymphoblastic leukemia (ALL; n = 129), acute myeloid leukemia (AML; n = 31) and CNS tumors (n = 158) was estimated using Cox proportional hazards models to generate hazard ratios (HR) and 95% confidence intervals (CI). Paternal exposures to pesticides and animals were associated with increased risk of childhood AML (herbicides HR = 3.22, 95% CI = 0.97–10.68; insecticides HR = 2.86, 95% CI = 0.99–8.23; animals HR = 3.89, 95% CI = 1.18–12.90), but not ALL or CNS tumors. Paternal exposure to organic dust was positively associated with AML (HR = 2.38 95% CI = 1.12–5.07), inversely associated with ALL (HR = 0.55, 95% CI = 0.31–0.99) and not associated with CNS tumors. Low exposure prevalence precluded evaluation of maternal pesticide and animal exposures; we observed no significant associations with organic dust exposure. This first prospective analysis of pooled birth cohorts and parental occupational exposures provides evidence for paternal agricultural exposures as childhood AML risk factors. The different risks for childhood ALL associated with maternal and paternal organic dust exposures should be investigated further.

AB - Parental occupational exposures to pesticides, animals and organic dust have been associated with an increased risk of childhood cancer based mostly on case–control studies. We prospectively evaluated parental occupational exposures and risk of childhood leukemia and central nervous system (CNS) tumors in the International Childhood Cancer Cohort Consortium. We pooled data on 329,658 participants from birth cohorts in five countries (Australia, Denmark, Israel, Norway and United Kingdom). Parental occupational exposures during pregnancy were estimated by linking International Standard Classification of Occupations-1988 job codes to the ALOHA+ job exposure matrix. Risk of childhood (<15 years) acute lymphoblastic leukemia (ALL; n = 129), acute myeloid leukemia (AML; n = 31) and CNS tumors (n = 158) was estimated using Cox proportional hazards models to generate hazard ratios (HR) and 95% confidence intervals (CI). Paternal exposures to pesticides and animals were associated with increased risk of childhood AML (herbicides HR = 3.22, 95% CI = 0.97–10.68; insecticides HR = 2.86, 95% CI = 0.99–8.23; animals HR = 3.89, 95% CI = 1.18–12.90), but not ALL or CNS tumors. Paternal exposure to organic dust was positively associated with AML (HR = 2.38 95% CI = 1.12–5.07), inversely associated with ALL (HR = 0.55, 95% CI = 0.31–0.99) and not associated with CNS tumors. Low exposure prevalence precluded evaluation of maternal pesticide and animal exposures; we observed no significant associations with organic dust exposure. This first prospective analysis of pooled birth cohorts and parental occupational exposures provides evidence for paternal agricultural exposures as childhood AML risk factors. The different risks for childhood ALL associated with maternal and paternal organic dust exposures should be investigated further.

KW - agricultural exposures

KW - animals

KW - childhood brain tumors

KW - childhood cancer

KW - childhood leukemia

KW - organic dust

KW - parental occupation

KW - pesticides

UR - http://www.scopus.com/inward/record.url?scp=85066310161&partnerID=8YFLogxK

U2 - 10.1002/ijc.32388

DO - 10.1002/ijc.32388

M3 - Article

C2 - 31054169

AN - SCOPUS:85066310161

SN - 0020-7136

VL - 146

SP - 943

EP - 952

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 4

ER -

Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C)

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this