Parotid salivary immunoglobulins, recurrent respiratory tract infections and gingival health in institutionalized and non-institutionalized subjects with Down's syndrome

Stella Chaushu*, E. Yefe Nof, A. Becker, J. Shapira, G. Chaushu

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    13 Scopus citations

    Abstract

    Background. The purpose of the present study was to evaluate the possible correlation between recurrent respiratory infections (RRIs), gingival health and the secretion rates of salivary immunoglobulins (Igs) in institutionalized (I) and non-institutionalized (NI) individuals with Down's syndrome (DS). Methods. Stimulated parotid saliva was collected from nine I and 14 NI subjects with DS. Salivary flow rate, secretion rates of total salivary IgM, IgG and IgA, and the incidence of RRIs were determined. Gingival health was recorded by using the plaque index, the gingival index and the percentage of bleeding surfaces (BS). Results. The mean salivary flow rate and parotid Ig secretion rates in the I group were 25% of those of the NI group. The prevalence of RRIs in the I group was more than twice that in the NI group. Oral hygiene and gingival health were significantly better in the NI group. Conclusions. The lower parotid Ig secretion rates in I individuals with DS might be a possible factor involved in their susceptibility to recurrent infections compared to NI subjects with DS.

    Original languageAmerican English
    Pages (from-to)101-107
    Number of pages7
    JournalJournal of Intellectual Disability Research
    Volume47
    Issue number2
    DOIs
    StatePublished - Feb 2003

    Keywords

    • Down's syndrome
    • Gingival health
    • Respiratory tract infections
    • Salivary immunoglobulins

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