Past and Present Insights on Alpha-linolenic Acid and the Omega-3 Fatty Acid Family

Aliza H. Stark, Ram Reifen*, Michael A. Crawford

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Alpha-linolenic acid (ALA) is the parent essential fatty acid of the omega-3 family. This family includes docosahexaenoic acid (DHA), which has been conserved in neural signaling systems in the cephalopods, fish, amphibian, reptiles, birds, mammals, primates, and humans. This extreme conservation, in spite of wide genomic changes of over 500 million years, testifies to the uniqueness of this molecule in the brain and affirms the importance of omega-3 fatty acids. While DHA and its close precursor, eicosapentaenoic acids (EPA), have received much attention by the research community, ALA, as the precursor of both, has been considered of little interest. There are many papers on ALA requirements in experimental animals. Unlike humans, rats and mice can readily convert ALA to EPA and DHA, so it is unclear whether the effect is solely due to the conversion products or to ALA itself. The intrinsic role of ALA has yet to be defined. This paper will discuss both recent and historical findings related to this distinctive group of fatty acids, and will highlight the physiological significance of the omega-3 family.

Original languageAmerican English
Pages (from-to)2261-2267
Number of pages7
JournalCritical Reviews in Food Science and Nutrition
Issue number14
StatePublished - 25 Oct 2016

Bibliographical note

Publisher Copyright:
© 2016, Copyright © Taylor & Francis Group, LLC.


  • Omega-3 fatty acids
  • alpha-linolenic acid
  • brain
  • docosahexaenoic acid


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