Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy

J. A. Obeso*, M. Stamelou, C. G. Goetz, W. Poewe, A. E. Lang, D. Weintraub, D. Burn, G. M. Halliday, E. Bezard, S. Przedborski, S. Lehericy, D. J. Brooks, J. C. Rothwell, M. Hallett, M. R. DeLong, C. Marras, C. M. Tanner, G. W. Ross, J. W. Langston, C. KleinV. Bonifati, J. Jankovic, A. M. Lozano, G. Deuschl, H. Bergman, E. Tolosa, M. Rodriguez-Violante, S. Fahn, R. B. Postuma, D. Berg, K. Marek, D. G. Standaert, D. J. Surmeier, C. W. Olanow, J. H. Kordower, P. Calabresi, A. H.V. Schapira, A. J. Stoessl

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

535 Scopus citations


This article reviews and summarizes 200 years of Parkinson's disease. It comprises a relevant history of Dr. James Parkinson's himself and what he described accurately and what he missed from today's perspective. Parkinson's disease today is understood as a multietiological condition with uncertain etiopathogenesis. Many advances have occurred regarding pathophysiology and symptomatic treatments, but critically important issues are still pending resolution. Among the latter, the need to modify disease progression is undoubtedly a priority. In sum, this multiple-author article, prepared to commemorate the bicentenary of the shaking palsy, provides a historical state-of-the-art account of what has been achieved, the current situation, and how to progress toward resolving Parkinson's disease.

Original languageAmerican English
Pages (from-to)1264-1310
Number of pages47
JournalMovement Disorders
Issue number9
StatePublished - Sep 2017

Bibliographical note

Publisher Copyright:
© 2017 International Parkinson and Movement Disorder Society


  • 200 years anniversary
  • Parkinson's disease
  • Shaking Palsy


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