TY - JOUR
T1 - Pasteurella multocida toxin induces IL-6, but not IL-1 alpha or TNF alpha in fibroblasts.
AU - Rosendal, S.
AU - Frandsen, P. L.
AU - Nielsen, J. P.
AU - Gallily, R.
PY - 1995/4
Y1 - 1995/4
N2 - Pasteurella multocida toxin (PMT) is the major virulence factor in Progressive Atrophic Rhinitis of swine. Other workers' previous findings that PMT was mitogenic for 3T3 fibroblasts, were confirmed in the present study. In addition, PMT stimulated 3T3 cells to release IL-6, but IL-1 alpha or TNF alpha were not detected in fibroblast supernatants sampled 24, 48, or 72 h after stimulation. In view of the role of IL-6 in osteoclastic bone resorption, these findings provide a new working hypothesis for investigations into the molecular pathogenesis of this important disease.
AB - Pasteurella multocida toxin (PMT) is the major virulence factor in Progressive Atrophic Rhinitis of swine. Other workers' previous findings that PMT was mitogenic for 3T3 fibroblasts, were confirmed in the present study. In addition, PMT stimulated 3T3 cells to release IL-6, but IL-1 alpha or TNF alpha were not detected in fibroblast supernatants sampled 24, 48, or 72 h after stimulation. In view of the role of IL-6 in osteoclastic bone resorption, these findings provide a new working hypothesis for investigations into the molecular pathogenesis of this important disease.
UR - http://www.scopus.com/inward/record.url?scp=0029283870&partnerID=8YFLogxK
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C2 - 7648529
AN - SCOPUS:0029283870
SN - 0830-9000
VL - 59
SP - 154
EP - 156
JO - Canadian Journal of Veterinary Research
JF - Canadian Journal of Veterinary Research
IS - 2
ER -