Paternal age and preeclampsia

Susan Harlap*, Ora Paltiel, Lisa Deutsch, Ariella Knaanie, Sausan Masalha, Efrat Tiram, Lee S. Caplan, Dolores Malaspina, Yechiel Friedlander

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

73 Scopus citations


Background. Paternal aging is associated with premeiotic damage to spermatogonia, a mechanism by which new point mutations are introduced into the gene pool. We hypothesized that paternal age might contribute to preeclampsia. Methods. We studied the incidence of preeclampsia in 81,213 deliveries surveyed in 1964-1976 in the Jerusalem Perinatal Study. We controlled for maternal age, parity and other risk factors using logistic regression. Results. Preeclampsia was reported in 1303 deliveries (1.6%). Compared with fathers age 25-34 years, the odds ratios (ORs) for preeclampsia were 1.24 (95% confidence interval = 1.05-1.46) for age 35-44 and 1.80 (1.40-2.31) for age 45+. For fathers age <25, the OR was 1.25 (1.04-1.51). Although weaker than maternal age effects, paternal effects were consistent within subgroups of other variables. Conclusions. These findings support the hypothesis that a modest proportion of preeclampsia might be explained by new mutations acquired from fathers and add to a growing body of evidence for paternal age effects in birth defects, neuropsychiatric disease and neoplasia.

Original languageAmerican English
Pages (from-to)660-667
Number of pages8
Issue number6
StatePublished - Nov 2002


  • Maternal age
  • New mutations
  • Paternal age
  • Preeclampsia
  • Risk factors
  • Spermatogenesis


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