Abstract
Lipid peroxidation (LPO) product accumulation in human tissues is a major cause of tissular and cellular dysfunction that plays a major role in ageing and most age-related and oxidative stress-related diseases. The current evidence for the implication of LPO in pathological processes is discussed in this review. New data and literature review are provided evaluating the role of LPO in the pathophysiology of ageing and classically oxidative stress-linked diseases, such as neurodegenerative diseases, diabetes and atherosclerosis (the main cause of cardiovascular complications). Striking evidences implicating LPO in foetal vascular dysfunction occurring in pre-eclampsia, in renal and liver diseases, as well as their role as cause and consequence to cancer development are addressed.
Original language | English |
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Pages (from-to) | 1125-1171 |
Number of pages | 47 |
Journal | Free Radical Research |
Volume | 44 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2010 |
Keywords
- 4-Hydroxynonenal
- 4-hydroxydodecadienal
- 4-hydroxynonenal
- Alzheimer ' s disease
- HELLP syndrome
- IUGR
- Nrf2
- Oxidative stress
- Parkinson ' s disease
- advanced glycation end-products
- amyotrophic lateral sclerosis
- antioxidant enzymes
- atherosclerosis
- cancer
- cell signalling
- diabetes
- diabetes complications
- fatty liver
- foetal endothelium
- glutathione
- hyperglycaemia
- lipid peroxidation
- liver disease
- lymphoedema
- neurodegenerative diseases
- oxidative homeostasis
- oxidized phospholipids
- oxysterol
- pre-eclampsia
- reactive oxygen species
- redox equilibrium
- redox signaling
- renal diseases