Pathological aspects of lipid peroxidation

Anne Negre-Salvayre; Nathalie Auge; Victoria Ayala; Huveyda Basaga; Jordi Boada; Rainer Brenke; Sarah Chapple; Guy Cohen; Janos Feher; Tilman Grune; Gabriella Lengyel; Giovanni E. Mann; Reinald Pamplona; Giuseppe Poli; Manuel Portero-Otin; Yael Riahi; Robert Salvayre; Shlomo Sasson; Jose Serrano; Ofer Shamni; Werner Siems; Richard C.M. Siow; Ingrid Wiswedel; Kamelija Zarkovic; Neven Zarkovic

doi:10.3109/10715762.2010.498478

Pathological aspects of lipid peroxidation

Anne Negre-Salvayre^*
, Nathalie Auge
, Victoria Ayala
, Huveyda Basaga
, Jordi Boada
, Rainer Brenke
, Sarah Chapple
, Guy Cohen
, Janos Feher
, Tilman Grune
, Gabriella Lengyel
, Giovanni E. Mann
, Reinald Pamplona
, Giuseppe Poli
, Manuel Portero-Otin
, Yael Riahi
, Robert Salvayre
, Shlomo Sasson
, Jose Serrano
, Ofer Shamni

Werner Siems, Richard C.M. Siow, Ingrid Wiswedel, Kamelija Zarkovic, Neven Zarkovic

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Review article › peer-review

397 Scopus citations

Abstract

Lipid peroxidation (LPO) product accumulation in human tissues is a major cause of tissular and cellular dysfunction that plays a major role in ageing and most age-related and oxidative stress-related diseases. The current evidence for the implication of LPO in pathological processes is discussed in this review. New data and literature review are provided evaluating the role of LPO in the pathophysiology of ageing and classically oxidative stress-linked diseases, such as neurodegenerative diseases, diabetes and atherosclerosis (the main cause of cardiovascular complications). Striking evidences implicating LPO in foetal vascular dysfunction occurring in pre-eclampsia, in renal and liver diseases, as well as their role as cause and consequence to cancer development are addressed.

Original language	English
Pages (from-to)	1125-1171
Number of pages	47
Journal	Free Radical Research
Volume	44
Issue number	10
DOIs	https://doi.org/10.3109/10715762.2010.498478
State	Published - Oct 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

4-Hydroxynonenal
4-hydroxydodecadienal
4-hydroxynonenal
Alzheimer ' s disease
HELLP syndrome
IUGR
Nrf2
Oxidative stress
Parkinson ' s disease
advanced glycation end-products
amyotrophic lateral sclerosis
antioxidant enzymes
atherosclerosis
cancer
cell signalling
diabetes
diabetes complications
fatty liver
foetal endothelium
glutathione
hyperglycaemia
lipid peroxidation
liver disease
lymphoedema
neurodegenerative diseases
oxidative homeostasis
oxidized phospholipids
oxysterol
pre-eclampsia
reactive oxygen species
redox equilibrium
redox signaling
renal diseases

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10.3109/10715762.2010.498478

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Negre-Salvayre, A., Auge, N., Ayala, V., Basaga, H., Boada, J., Brenke, R., Chapple, S., Cohen, G., Feher, J., Grune, T., Lengyel, G., Mann, G. E., Pamplona, R., Poli, G., Portero-Otin, M., Riahi, Y., Salvayre, R., Sasson, S., Serrano, J., ... Zarkovic, N. (2010). Pathological aspects of lipid peroxidation. Free Radical Research, 44(10), 1125-1171. https://doi.org/10.3109/10715762.2010.498478

@article{7436bb87e7fb4806b23d4b96f52b3860,

title = "Pathological aspects of lipid peroxidation",

abstract = "Lipid peroxidation (LPO) product accumulation in human tissues is a major cause of tissular and cellular dysfunction that plays a major role in ageing and most age-related and oxidative stress-related diseases. The current evidence for the implication of LPO in pathological processes is discussed in this review. New data and literature review are provided evaluating the role of LPO in the pathophysiology of ageing and classically oxidative stress-linked diseases, such as neurodegenerative diseases, diabetes and atherosclerosis (the main cause of cardiovascular complications). Striking evidences implicating LPO in foetal vascular dysfunction occurring in pre-eclampsia, in renal and liver diseases, as well as their role as cause and consequence to cancer development are addressed.",

keywords = "4-Hydroxynonenal, 4-hydroxydodecadienal, 4-hydroxynonenal, Alzheimer ' s disease, HELLP syndrome, IUGR, Nrf2, Oxidative stress, Parkinson ' s disease, advanced glycation end-products, amyotrophic lateral sclerosis, antioxidant enzymes, atherosclerosis, cancer, cell signalling, diabetes, diabetes complications, fatty liver, foetal endothelium, glutathione, hyperglycaemia, lipid peroxidation, liver disease, lymphoedema, neurodegenerative diseases, oxidative homeostasis, oxidized phospholipids, oxysterol, pre-eclampsia, reactive oxygen species, redox equilibrium, redox signaling, renal diseases",

author = "Anne Negre-Salvayre and Nathalie Auge and Victoria Ayala and Huveyda Basaga and Jordi Boada and Rainer Brenke and Sarah Chapple and Guy Cohen and Janos Feher and Tilman Grune and Gabriella Lengyel and Mann, \{Giovanni E.\} and Reinald Pamplona and Giuseppe Poli and Manuel Portero-Otin and Yael Riahi and Robert Salvayre and Shlomo Sasson and Jose Serrano and Ofer Shamni and Werner Siems and Siow, \{Richard C.M.\} and Ingrid Wiswedel and Kamelija Zarkovic and Neven Zarkovic",

year = "2010",

month = oct,

doi = "10.3109/10715762.2010.498478",

language = "אנגלית",

volume = "44",

pages = "1125--1171",

journal = "Free Radical Research",

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Negre-Salvayre, A, Auge, N, Ayala, V, Basaga, H, Boada, J, Brenke, R, Chapple, S, Cohen, G, Feher, J, Grune, T, Lengyel, G, Mann, GE, Pamplona, R, Poli, G, Portero-Otin, M, Riahi, Y, Salvayre, R, Sasson, S, Serrano, J, Shamni, O, Siems, W, Siow, RCM, Wiswedel, I, Zarkovic, K & Zarkovic, N 2010, 'Pathological aspects of lipid peroxidation', Free Radical Research, vol. 44, no. 10, pp. 1125-1171. https://doi.org/10.3109/10715762.2010.498478

TY - JOUR

T1 - Pathological aspects of lipid peroxidation

AU - Negre-Salvayre, Anne

AU - Auge, Nathalie

AU - Ayala, Victoria

AU - Basaga, Huveyda

AU - Boada, Jordi

AU - Brenke, Rainer

AU - Chapple, Sarah

AU - Cohen, Guy

AU - Feher, Janos

AU - Grune, Tilman

AU - Lengyel, Gabriella

AU - Mann, Giovanni E.

AU - Pamplona, Reinald

AU - Poli, Giuseppe

AU - Portero-Otin, Manuel

AU - Riahi, Yael

AU - Salvayre, Robert

AU - Sasson, Shlomo

AU - Serrano, Jose

AU - Shamni, Ofer

AU - Siems, Werner

AU - Siow, Richard C.M.

AU - Wiswedel, Ingrid

AU - Zarkovic, Kamelija

AU - Zarkovic, Neven

PY - 2010/10

Y1 - 2010/10

N2 - Lipid peroxidation (LPO) product accumulation in human tissues is a major cause of tissular and cellular dysfunction that plays a major role in ageing and most age-related and oxidative stress-related diseases. The current evidence for the implication of LPO in pathological processes is discussed in this review. New data and literature review are provided evaluating the role of LPO in the pathophysiology of ageing and classically oxidative stress-linked diseases, such as neurodegenerative diseases, diabetes and atherosclerosis (the main cause of cardiovascular complications). Striking evidences implicating LPO in foetal vascular dysfunction occurring in pre-eclampsia, in renal and liver diseases, as well as their role as cause and consequence to cancer development are addressed.

AB - Lipid peroxidation (LPO) product accumulation in human tissues is a major cause of tissular and cellular dysfunction that plays a major role in ageing and most age-related and oxidative stress-related diseases. The current evidence for the implication of LPO in pathological processes is discussed in this review. New data and literature review are provided evaluating the role of LPO in the pathophysiology of ageing and classically oxidative stress-linked diseases, such as neurodegenerative diseases, diabetes and atherosclerosis (the main cause of cardiovascular complications). Striking evidences implicating LPO in foetal vascular dysfunction occurring in pre-eclampsia, in renal and liver diseases, as well as their role as cause and consequence to cancer development are addressed.

KW - 4-Hydroxynonenal

KW - 4-hydroxydodecadienal

KW - 4-hydroxynonenal

KW - Alzheimer ' s disease

KW - HELLP syndrome

KW - IUGR

KW - Nrf2

KW - Oxidative stress

KW - Parkinson ' s disease

KW - advanced glycation end-products

KW - amyotrophic lateral sclerosis

KW - antioxidant enzymes

KW - atherosclerosis

KW - cancer

KW - cell signalling

KW - diabetes

KW - diabetes complications

KW - fatty liver

KW - foetal endothelium

KW - glutathione

KW - hyperglycaemia

KW - lipid peroxidation

KW - liver disease

KW - lymphoedema

KW - neurodegenerative diseases

KW - oxidative homeostasis

KW - oxidized phospholipids

KW - oxysterol

KW - pre-eclampsia

KW - reactive oxygen species

KW - redox equilibrium

KW - redox signaling

KW - renal diseases

UR - https://www.scopus.com/pages/publications/77956574773

U2 - 10.3109/10715762.2010.498478

DO - 10.3109/10715762.2010.498478

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C2 - 20836660

AN - SCOPUS:77956574773

SN - 1071-5762

VL - 44

SP - 1125

EP - 1171

JO - Free Radical Research

JF - Free Radical Research

IS - 10

ER -

Pathological aspects of lipid peroxidation

Abstract

UN SDGs

Keywords

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