Pathological synchronization in Parkinson's disease: networks, models and treatments

Constance Hammond*, Hagai Bergman, Peter Brown

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1236 Scopus citations

Abstract

Parkinson's disease is a common and disabling disorder of movement owing to dopaminergic denervation of the striatum. However, it is still unclear how this denervation perverts normal functioning to cause slowing of voluntary movements. Recent work using tissue slice preparations, animal models and in humans with Parkinson's disease has demonstrated abnormally synchronized oscillatory activity at multiple levels of the basal ganglia-cortical loop. This excessive synchronization correlates with motor deficit, and its suppression by dopaminergic therapies, ablative surgery or deep-brain stimulation might provide the basic mechanism whereby diverse therapeutic strategies ameliorate motor impairment in patients with Parkinson's disease. This review is part of the INMED/TINS special issue, Physiogenic and pathogenic oscillations: the beauty and the beast, based on presentations at the annual INMED/TINS symposium (http://inmednet.com/).

Original languageAmerican English
Pages (from-to)357-364
Number of pages8
JournalTrends in Neurosciences
Volume30
Issue number7
DOIs
StatePublished - Jul 2007

Bibliographical note

Funding Information:
P.B. was supported by the Medical Research Council, UK; H.B. was supported by the ‘Fighting against Parkinson’ Foundation of the Hebrew University Netherlands Association (HUNA); C.H. was supported by CNRS, Inserm and Fondation de France. C.H. thanks Liliana Garcia, Rachida Ammari and Bernard Bioulac.

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