Summary: PDZBase is a database that aims to contain all known PDZ-domain-mediated protein-protein interactions. Currently, PDZ-Base contains approximately 300 such interactions, which have been manually extracted from >200 articles. The database can be queried through both sequence motif and keyword-based searches, and the sequences of interacting proteins can be visually inspected through alignments (for the comparison of several interactions), or as residue-based diagrams including schematic secondary structure information (for individual complexes).
Bibliographical noteFunding Information:
We thank Dr Nathalie Basdevant for curating part of the interactions. The work is supported by NIH grants K05 DA00060, P01 DA124080 and P01 DA12923.