Peanut agglutinin as a marker of maturation and activation of chicken thymic-derived lymphocytes.

Z. Uni*, E. D. Heller

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


In mammals peanut agglutinin (PNA) is used for separation of lymphocytes into immature and mature T-cells. Lymphocytes that bind PNA are young and functionally immature, but the cells that do not bind PNA are considered mature. No conclusive information was published on PNA as a marker of lymphocytes maturation in chickens. The present results showed that T-lymphocytes that do not bind PNA (PNA-) responded significantly higher to Concanavalin A (Con-A) stimulation than PNA+ ones. During Con-A activation, a PNA receptor was revealed. Double staining of Con-A cultured lymphocytes revealed the presence of both I-associated antigen and PNA. Therefore, the PNA receptor, on chicken T-lymphocytes, was not indicative always of immaturity. During maturation, the receptor was covered and the cells were PNA-, but subsequent proliferation reverted PNA- cells to PNA+ cells.

Original languageAmerican English
Pages (from-to)1516-1520
Number of pages5
JournalPoultry Science
Issue number7
StatePublished - Jul 1991

Bibliographical note

Funding Information:
This study was supported by the Binational Agricultural Research and Development Fund (US-829-84). The authors are most grateful to K. A. Schat for his advice and help.


Dive into the research topics of 'Peanut agglutinin as a marker of maturation and activation of chicken thymic-derived lymphocytes.'. Together they form a unique fingerprint.

Cite this