TY - JOUR
T1 - Pearls & Oy-sters
T2 - Reversible Postpartum Pseudocoma State Associated With Magnesium Therapy: A Report of 2 Cases
AU - Friedman-Korn, Tal
AU - Lerner, Yosef
AU - Haggiag, Shalom
AU - Nama, Ahmad
AU - Ekstein, Dana
AU - Argov, Zohar
AU - Vaknin-Dembinsky, Adi
AU - Gotkine, Marc
N1 - Publisher Copyright:
© American Academy of Neurology.
PY - 2022/9/6
Y1 - 2022/9/6
N2 - Magnesium (Mg) competes with calcium in normal synaptic transmission, inhibiting neurotransmitter release. As a drug, it is usually given as a treatment for eclampsia and preeclampsia. Two eclamptic pregnant women treated with Mg developed a pseudocoma state immediately after emergency Caesarian section. The clinical presentation was flaccid quadriparesis, areflexia, absent respiratory effort and vestibular-ocular reflexes, but with preserved pupillary responses. Decremental responses on repetitive nerve stimulation were found in both women. Recovery was obtained after cessation of Mg. The persistence of pupillary reflexes in the absence of reflexes involving striated muscles was an important clinical clue, indicating neuromuscular junction dysfunction.
AB - Magnesium (Mg) competes with calcium in normal synaptic transmission, inhibiting neurotransmitter release. As a drug, it is usually given as a treatment for eclampsia and preeclampsia. Two eclamptic pregnant women treated with Mg developed a pseudocoma state immediately after emergency Caesarian section. The clinical presentation was flaccid quadriparesis, areflexia, absent respiratory effort and vestibular-ocular reflexes, but with preserved pupillary responses. Decremental responses on repetitive nerve stimulation were found in both women. Recovery was obtained after cessation of Mg. The persistence of pupillary reflexes in the absence of reflexes involving striated muscles was an important clinical clue, indicating neuromuscular junction dysfunction.
UR - http://www.scopus.com/inward/record.url?scp=85138157465&partnerID=8YFLogxK
U2 - 10.1212/wnl.0000000000200956
DO - 10.1212/wnl.0000000000200956
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C2 - 36219798
AN - SCOPUS:85138157465
SN - 0028-3878
VL - 99
SP - 433
EP - 436
JO - Neurology
JF - Neurology
IS - 10
ER -