PEG-coated nanospheres from amphiphilic diblock and multiblock copolymers: Investigation of their drug encapsulation and release characteristics

Maria Teresa Peracchia, Ruxandra Gref, Yoshiharu Minamitake, Avi Domb, Noah Lotan, Robert Langer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

281 Scopus citations

Abstract

The development of long-circulating carriers capable of continuously delivering drugs intravenously provides a potential approach to achieve targeting of drugs to specific sites of action. In this research, polyethylene glycol (PEG)-coated nanospheres were prepared in a single step process using amphiphilic diblock and multiblock copolymers, and their drug encapsulation properties and release characteristics were investigated in vitro. The results obtained indicate that the parameters controlling drug release characteristics of these nanospheres are the chemical composition of their hydrophobic core (i.e. polyester or polyanhydride), as well as the molecular weight and surface density of their hydrophilic (i.e. PEG) chains.

Original languageEnglish
Pages (from-to)223-231
Number of pages9
JournalJournal of Controlled Release
Volume46
Issue number3
DOIs
StatePublished - 2 Jun 1997
Externally publishedYes

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