TY - JOUR
T1 - PEG-coated nanospheres from amphiphilic diblock and multiblock copolymers
T2 - Investigation of their drug encapsulation and release characteristics
AU - Peracchia, Maria Teresa
AU - Gref, Ruxandra
AU - Minamitake, Yoshiharu
AU - Domb, Avi
AU - Lotan, Noah
AU - Langer, Robert
PY - 1997/6/2
Y1 - 1997/6/2
N2 - The development of long-circulating carriers capable of continuously delivering drugs intravenously provides a potential approach to achieve targeting of drugs to specific sites of action. In this research, polyethylene glycol (PEG)-coated nanospheres were prepared in a single step process using amphiphilic diblock and multiblock copolymers, and their drug encapsulation properties and release characteristics were investigated in vitro. The results obtained indicate that the parameters controlling drug release characteristics of these nanospheres are the chemical composition of their hydrophobic core (i.e. polyester or polyanhydride), as well as the molecular weight and surface density of their hydrophilic (i.e. PEG) chains.
AB - The development of long-circulating carriers capable of continuously delivering drugs intravenously provides a potential approach to achieve targeting of drugs to specific sites of action. In this research, polyethylene glycol (PEG)-coated nanospheres were prepared in a single step process using amphiphilic diblock and multiblock copolymers, and their drug encapsulation properties and release characteristics were investigated in vitro. The results obtained indicate that the parameters controlling drug release characteristics of these nanospheres are the chemical composition of their hydrophobic core (i.e. polyester or polyanhydride), as well as the molecular weight and surface density of their hydrophilic (i.e. PEG) chains.
UR - http://www.scopus.com/inward/record.url?scp=0030948510&partnerID=8YFLogxK
U2 - 10.1016/S0168-3659(96)01597-0
DO - 10.1016/S0168-3659(96)01597-0
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AN - SCOPUS:0030948510
SN - 0168-3659
VL - 46
SP - 223
EP - 231
JO - Journal of Controlled Release
JF - Journal of Controlled Release
IS - 3
ER -