Pellet formation and cellular aggregation in Streptomyces tendae

S. E. Vecht‐Lifshitz, S. Magdassi, S. Braun*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

95 Scopus citations


In submerged cultures, Streptomyces tendae tended to form fluffy spherical pellets of the noncoagulative type. An increase in the average pellet size could be attained by decreasing any of the following: shear rate, pH, temperature, or inoculum size. Conditions leading to oxygen limitation tended to reduce the average pellet size and induced pulpy growth, whereas oxygen sufficiency seemed to induce pellet formation. Factors inducing pellet formation simultaneously increased cell wall hydrophobicity. It is therefore proposed that the main forces inducing cellular aggregation in S. tendae are hydrophobic interactions of cell walls, and these interactions are controlled by availability of dissolved oxygen.

Original languageAmerican English
Pages (from-to)890-896
Number of pages7
JournalBiotechnology and Bioengineering
Issue number9
StatePublished - 15 Apr 1990


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