Peptide nanotube-modified electrodes for enzyme-biosensor applications

Miri Yemini, Meital Reches, Ehud Gazit, Judith Rishpon*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

237 Scopus citations


The fabrication and notably improved performance of composite electrodes based on modified self-assembled diphenylalanine peptide nanotubes is described. Peptide nanotubes were attached to gold electrodes, and we studied the resulting electrochemical behavior using cyclic voltammetry and chronoamperometry. The peptide nanotube-based electrodes demonstrated a direct and unmediated response to hydrogen peroxide and NADH at a potential of +0.4 V (vs SCE). This biosensor enables a sensitive determination of glucose by monitoring the hydrogen peroxide produced by an enzymatic reaction between the glucose oxidase attached to the peptide nanotubes and glucose. In addition, the marked electrocatalytic activity toward NADH enabled a sensitive detection of ethanol using ethanol dehydrogenase and NAD+. The peptide nanotube-based amperometric biosensor provides a potential new tool for sensitive biosensors and biomolecular diagnostics.

Original languageAmerican English
Pages (from-to)5155-5159
Number of pages5
JournalAnalytical Chemistry
Issue number16
StatePublished - 15 Aug 2005
Externally publishedYes


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