Peptiderive server: derive peptide inhibitors from protein-protein interactions

Yuval Sedan, Orly Marcu, Sergey Lyskov, Ora Schueler-Furman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


The Rosetta Peptiderive protocol identifies, in a given structure of a protein-protein interaction, the linear polypeptide segment suggested to contribute most to binding energy. Interactions that feature a 'hot segment', a linear peptide with significant binding energy compared to that of the complex, may be amenable for inhibition and the peptide sequence and structure derived from the interaction provide a starting point for rational drug design. Here we present a web server for Peptiderive, which is incorporated within the ROSIE web interface for Rosetta protocols. A new feature of the protocol also evaluates whether derived peptides are good candidates for cyclization. Fast computation times and clear visualization allow users to quickly assess the interaction of interest. The Peptiderive server is available for free use at

Original languageAmerican English
Pages (from-to)W536-W541
JournalNucleic Acids Research
Issue number1
StatePublished - 1 Aug 2016

Bibliographical note

Publisher Copyright:
© The Author(s) 2016.


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