Peptides form stereoselective complexes with chiral polymers

Joram Slager; Yachin Cohen; Rafail Khalfin; Yeshayahu Talmon; Abraham J. Domb

doi:10.1021/ma025753f

Peptides form stereoselective complexes with chiral polymers

Joram Slager, Yachin Cohen, Rafail Khalfin, Yeshayahu Talmon, Abraham J. Domb^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Reversible stereoselective complexes between L-peptides and enantioselective D-polysters were discovered. The spontaneously formed complexes obtained as uniform microparticles of 2-5μm in size showed controlled release of the interlocked peptides. The stereoselective complexation occurred only with D-PLA, not with L-PLA or racemic DL-PLA as shown by SAXS studies.

Original language	English
Pages (from-to)	2999-3000
Number of pages	2
Journal	Macromolecules
Volume	36
Issue number	9
DOIs	https://doi.org/10.1021/ma025753f
State	Published - 6 May 2003

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abstract = "Reversible stereoselective complexes between L-peptides and enantioselective D-polysters were discovered. The spontaneously formed complexes obtained as uniform microparticles of 2-5μm in size showed controlled release of the interlocked peptides. The stereoselective complexation occurred only with D-PLA, not with L-PLA or racemic DL-PLA as shown by SAXS studies.",

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AU - Slager, Joram

AU - Cohen, Yachin

AU - Khalfin, Rafail

AU - Talmon, Yeshayahu

AU - Domb, Abraham J.

PY - 2003/5/6

Y1 - 2003/5/6

N2 - Reversible stereoselective complexes between L-peptides and enantioselective D-polysters were discovered. The spontaneously formed complexes obtained as uniform microparticles of 2-5μm in size showed controlled release of the interlocked peptides. The stereoselective complexation occurred only with D-PLA, not with L-PLA or racemic DL-PLA as shown by SAXS studies.

AB - Reversible stereoselective complexes between L-peptides and enantioselective D-polysters were discovered. The spontaneously formed complexes obtained as uniform microparticles of 2-5μm in size showed controlled release of the interlocked peptides. The stereoselective complexation occurred only with D-PLA, not with L-PLA or racemic DL-PLA as shown by SAXS studies.

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Peptides form stereoselective complexes with chiral polymers

Abstract

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