Perinatal photoperiod and childhood cancer: pooled results from 182,856 individuals in the international childhood cancer cohort consortium (I4C)

Philip Lewis; Martin Hellmich; Lin Fritschi; Gabriella Tikellis; Peter Morfeld; J. Valérie Groß; Russell G. Foster; Ora Paltiel; Mark A. Klebanoff; Jean Golding; Sjurdur Olsen; Per Magnus; Anne Louise Ponsonby; Martha S. Linet; Mary H. Ward; Neil Caporaso; Terence Dwyer; Thomas C. Erren

doi:10.1080/07420528.2020.1740724

Perinatal photoperiod and childhood cancer: pooled results from 182,856 individuals in the international childhood cancer cohort consortium (I4C)

Philip Lewis^*, Martin Hellmich, Lin Fritschi, Gabriella Tikellis, Peter Morfeld, J. Valérie Groß, Russell G. Foster, Ora Paltiel, Mark A. Klebanoff, Jean Golding, Sjurdur Olsen, Per Magnus, Anne Louise Ponsonby, Martha S. Linet, Mary H. Ward, Neil Caporaso, Terence Dwyer, Thomas C. Erren

^*Corresponding author for this work

Braun School of Public Health and Community Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Experimental evidence suggests that perinatal light imprinting of circadian clocks and systems may affect downstream physiology and cancer risk in later life. For humans, the predominant circadian stimulus is the daily light-dark cycle. Herein, we explore associations between perinatal photoperiod characteristics (photoperiod: duration of daylight as determined by time-of-year and location) and childhood cancer risk. We use pooled data on 182,856 mothers and babies from prospective birth cohorts in six countries (Australia, Denmark, Israel, Norway, UK, USA) within the International Childhood Cancer Cohort Consortium (I4C). Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). In line with predicted differential dose–responses, restricted cubic splines indicate a potential non-linear, non-monotonic relationship between perinatal mean daily photoperiod (0–24 h) and childhood cancer risk. In a restricted analysis of 154,121 individuals who experienced third trimester photoperiods exclusively within the 8–16-h range, the relative risk of developing childhood cancer decreased by 9% with every hour increase in third trimester mean daily photoperiod [HR: 0.91 (95%CIs: 0.84–0.99)]. In conclusion, in this first study of perinatal photoperiod and childhood cancer, we detected an inverse [“protective”] linear association between third trimester mean daily photoperiod and childhood cancer risk in the 8–16-h set of the total study population. Limited statistical power impeded the investigation of risks with individuals exposed to more extreme photoperiods. Future studies are needed to confirm differential photoperiod-associated risks and further investigations into the hypothesized circadian imprinting mechanism are warranted.

Original language	American English
Pages (from-to)	1034-1047
Number of pages	14
Journal	Chronobiology International
Volume	37
Issue number	7
DOIs	https://doi.org/10.1080/07420528.2020.1740724
State	Published - 2 Jul 2020

Bibliographical note

Funding Information:
The NIH intramural research program (NCI, NICHD)–USA; National Children’s Study–USA; Tour de Cure–Australia; the Children’s Cancer Centre Foundation - Australia; Bluey Day Foundation–Australia; Baxter Family Foundation–Australia; The Rotary Club of North Brighton–Australia; Private philanthropic donations–Australia; and Murdoch Children’s Research Institution [M1300049], Australia. The UK Medical Research Council and the Wellcome Trust [Grant ref: 092731] and the University of Bristol currently provide core support for ALSPAC. The Maria Ascoli Foundation, Jerusalem, Israel, provided support for data pooling of the JPS. We are extremely grateful to all the families who took part in the respective cohorts, medical personnel, and the individuals involved in recruitment, data collection, organization, and upkeep of the respective cohorts and the I4C consortium. We also thank Dr. Frank Steffany (University of Cologne) for lending expert meteorological expertise at the beginning of this project.

Publisher Copyright:
© 2020 Taylor & Francis Group, LLC.

Keywords

PLICCS
Perinatal
childhood cancer
circadian
cohort
leukemia
light

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/07420528.2020.1740724

Cite this

Lewis, P., Hellmich, M., Fritschi, L., Tikellis, G., Morfeld, P., Groß, J. V., Foster, R. G., Paltiel, O., Klebanoff, M. A., Golding, J., Olsen, S., Magnus, P., Ponsonby, A. L., Linet, M. S., Ward, M. H., Caporaso, N., Dwyer, T., & Erren, T. C. (2020). Perinatal photoperiod and childhood cancer: pooled results from 182,856 individuals in the international childhood cancer cohort consortium (I4C). Chronobiology International, 37(7), 1034-1047. https://doi.org/10.1080/07420528.2020.1740724

@article{20b0e2986227496485237e69560b636d,

title = "Perinatal photoperiod and childhood cancer: pooled results from 182,856 individuals in the international childhood cancer cohort consortium (I4C)",

abstract = "Experimental evidence suggests that perinatal light imprinting of circadian clocks and systems may affect downstream physiology and cancer risk in later life. For humans, the predominant circadian stimulus is the daily light-dark cycle. Herein, we explore associations between perinatal photoperiod characteristics (photoperiod: duration of daylight as determined by time-of-year and location) and childhood cancer risk. We use pooled data on 182,856 mothers and babies from prospective birth cohorts in six countries (Australia, Denmark, Israel, Norway, UK, USA) within the International Childhood Cancer Cohort Consortium (I4C). Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). In line with predicted differential dose–responses, restricted cubic splines indicate a potential non-linear, non-monotonic relationship between perinatal mean daily photoperiod (0–24 h) and childhood cancer risk. In a restricted analysis of 154,121 individuals who experienced third trimester photoperiods exclusively within the 8–16-h range, the relative risk of developing childhood cancer decreased by 9% with every hour increase in third trimester mean daily photoperiod [HR: 0.91 (95%CIs: 0.84–0.99)]. In conclusion, in this first study of perinatal photoperiod and childhood cancer, we detected an inverse [“protective”] linear association between third trimester mean daily photoperiod and childhood cancer risk in the 8–16-h set of the total study population. Limited statistical power impeded the investigation of risks with individuals exposed to more extreme photoperiods. Future studies are needed to confirm differential photoperiod-associated risks and further investigations into the hypothesized circadian imprinting mechanism are warranted.",

keywords = "PLICCS, Perinatal, childhood cancer, circadian, cohort, leukemia, light",

author = "Philip Lewis and Martin Hellmich and Lin Fritschi and Gabriella Tikellis and Peter Morfeld and Gro{\ss}, {J. Val{\'e}rie} and Foster, {Russell G.} and Ora Paltiel and Klebanoff, {Mark A.} and Jean Golding and Sjurdur Olsen and Per Magnus and Ponsonby, {Anne Louise} and Linet, {Martha S.} and Ward, {Mary H.} and Neil Caporaso and Terence Dwyer and Erren, {Thomas C.}",

note = "Funding Information: The NIH intramural research program (NCI, NICHD)–USA; National Children{\textquoteright}s Study–USA; Tour de Cure–Australia; the Children{\textquoteright}s Cancer Centre Foundation - Australia; Bluey Day Foundation–Australia; Baxter Family Foundation–Australia; The Rotary Club of North Brighton–Australia; Private philanthropic donations–Australia; and Murdoch Children{\textquoteright}s Research Institution [M1300049], Australia. The UK Medical Research Council and the Wellcome Trust [Grant ref: 092731] and the University of Bristol currently provide core support for ALSPAC. The Maria Ascoli Foundation, Jerusalem, Israel, provided support for data pooling of the JPS. We are extremely grateful to all the families who took part in the respective cohorts, medical personnel, and the individuals involved in recruitment, data collection, organization, and upkeep of the respective cohorts and the I4C consortium. We also thank Dr. Frank Steffany (University of Cologne) for lending expert meteorological expertise at the beginning of this project. Publisher Copyright: {\textcopyright} 2020 Taylor & Francis Group, LLC.",

year = "2020",

month = jul,

day = "2",

doi = "10.1080/07420528.2020.1740724",

language = "American English",

volume = "37",

pages = "1034--1047",

journal = "Chronobiology International",

issn = "0742-0528",

publisher = "Informa Healthcare",

number = "7",

}

Lewis, P, Hellmich, M, Fritschi, L, Tikellis, G, Morfeld, P, Groß, JV, Foster, RG, Paltiel, O, Klebanoff, MA, Golding, J, Olsen, S, Magnus, P, Ponsonby, AL, Linet, MS, Ward, MH, Caporaso, N, Dwyer, T & Erren, TC 2020, 'Perinatal photoperiod and childhood cancer: pooled results from 182,856 individuals in the international childhood cancer cohort consortium (I4C)', Chronobiology International, vol. 37, no. 7, pp. 1034-1047. https://doi.org/10.1080/07420528.2020.1740724

TY - JOUR

T1 - Perinatal photoperiod and childhood cancer

T2 - pooled results from 182,856 individuals in the international childhood cancer cohort consortium (I4C)

AU - Lewis, Philip

AU - Hellmich, Martin

AU - Fritschi, Lin

AU - Tikellis, Gabriella

AU - Morfeld, Peter

AU - Groß, J. Valérie

AU - Foster, Russell G.

AU - Paltiel, Ora

AU - Klebanoff, Mark A.

AU - Golding, Jean

AU - Olsen, Sjurdur

AU - Magnus, Per

AU - Ponsonby, Anne Louise

AU - Linet, Martha S.

AU - Ward, Mary H.

AU - Caporaso, Neil

AU - Dwyer, Terence

AU - Erren, Thomas C.

N1 - Funding Information: The NIH intramural research program (NCI, NICHD)–USA; National Children’s Study–USA; Tour de Cure–Australia; the Children’s Cancer Centre Foundation - Australia; Bluey Day Foundation–Australia; Baxter Family Foundation–Australia; The Rotary Club of North Brighton–Australia; Private philanthropic donations–Australia; and Murdoch Children’s Research Institution [M1300049], Australia. The UK Medical Research Council and the Wellcome Trust [Grant ref: 092731] and the University of Bristol currently provide core support for ALSPAC. The Maria Ascoli Foundation, Jerusalem, Israel, provided support for data pooling of the JPS. We are extremely grateful to all the families who took part in the respective cohorts, medical personnel, and the individuals involved in recruitment, data collection, organization, and upkeep of the respective cohorts and the I4C consortium. We also thank Dr. Frank Steffany (University of Cologne) for lending expert meteorological expertise at the beginning of this project. Publisher Copyright: © 2020 Taylor & Francis Group, LLC.

PY - 2020/7/2

Y1 - 2020/7/2

N2 - Experimental evidence suggests that perinatal light imprinting of circadian clocks and systems may affect downstream physiology and cancer risk in later life. For humans, the predominant circadian stimulus is the daily light-dark cycle. Herein, we explore associations between perinatal photoperiod characteristics (photoperiod: duration of daylight as determined by time-of-year and location) and childhood cancer risk. We use pooled data on 182,856 mothers and babies from prospective birth cohorts in six countries (Australia, Denmark, Israel, Norway, UK, USA) within the International Childhood Cancer Cohort Consortium (I4C). Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). In line with predicted differential dose–responses, restricted cubic splines indicate a potential non-linear, non-monotonic relationship between perinatal mean daily photoperiod (0–24 h) and childhood cancer risk. In a restricted analysis of 154,121 individuals who experienced third trimester photoperiods exclusively within the 8–16-h range, the relative risk of developing childhood cancer decreased by 9% with every hour increase in third trimester mean daily photoperiod [HR: 0.91 (95%CIs: 0.84–0.99)]. In conclusion, in this first study of perinatal photoperiod and childhood cancer, we detected an inverse [“protective”] linear association between third trimester mean daily photoperiod and childhood cancer risk in the 8–16-h set of the total study population. Limited statistical power impeded the investigation of risks with individuals exposed to more extreme photoperiods. Future studies are needed to confirm differential photoperiod-associated risks and further investigations into the hypothesized circadian imprinting mechanism are warranted.

AB - Experimental evidence suggests that perinatal light imprinting of circadian clocks and systems may affect downstream physiology and cancer risk in later life. For humans, the predominant circadian stimulus is the daily light-dark cycle. Herein, we explore associations between perinatal photoperiod characteristics (photoperiod: duration of daylight as determined by time-of-year and location) and childhood cancer risk. We use pooled data on 182,856 mothers and babies from prospective birth cohorts in six countries (Australia, Denmark, Israel, Norway, UK, USA) within the International Childhood Cancer Cohort Consortium (I4C). Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). In line with predicted differential dose–responses, restricted cubic splines indicate a potential non-linear, non-monotonic relationship between perinatal mean daily photoperiod (0–24 h) and childhood cancer risk. In a restricted analysis of 154,121 individuals who experienced third trimester photoperiods exclusively within the 8–16-h range, the relative risk of developing childhood cancer decreased by 9% with every hour increase in third trimester mean daily photoperiod [HR: 0.91 (95%CIs: 0.84–0.99)]. In conclusion, in this first study of perinatal photoperiod and childhood cancer, we detected an inverse [“protective”] linear association between third trimester mean daily photoperiod and childhood cancer risk in the 8–16-h set of the total study population. Limited statistical power impeded the investigation of risks with individuals exposed to more extreme photoperiods. Future studies are needed to confirm differential photoperiod-associated risks and further investigations into the hypothesized circadian imprinting mechanism are warranted.

KW - PLICCS

KW - Perinatal

KW - childhood cancer

KW - circadian

KW - cohort

KW - leukemia

KW - light

UR - http://www.scopus.com/inward/record.url?scp=85082758889&partnerID=8YFLogxK

U2 - 10.1080/07420528.2020.1740724

DO - 10.1080/07420528.2020.1740724

M3 - Article

C2 - 32233647

AN - SCOPUS:85082758889

SN - 0742-0528

VL - 37

SP - 1034

EP - 1047

JO - Chronobiology International

JF - Chronobiology International

IS - 7

ER -

Perinatal photoperiod and childhood cancer: pooled results from 182,856 individuals in the international childhood cancer cohort consortium (I4C)

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this