Permanent neurological complications in patients with thrombotic thrombocytopenic purpura

Dina Ben‐Yehuda, Michal Rose, Yossef Michaeli, Amiram Eldor*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

According to previous clinical studies, the neurological manifestations observed in patients with thrombotic thrombocytopenic purpura (TTP) are considered to be transient. The introduction of plasma therapy in 1977 as major treatment modality for TTP has changed the prognosis of the disease. In a clinical survey of 38 patients with TTP who received plasma therapy, we have observed five patients who developed permanent neurological deficits despite their prompt recovery from TTP. In this study, we describe the new complication of TTP and summarize the neurological manifestations observed in these patients during their first episode of TTP and during the relapses, which occurred in 12 of them.

Original languageAmerican English
Pages (from-to)74-78
Number of pages5
JournalAmerican Journal of Hematology
Volume29
Issue number2
DOIs
StatePublished - Oct 1988
Externally publishedYes

Keywords

  • neurological deficits
  • thrombotic thrombocytopenic purpura

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