Perturbations in the replication program contribute to genomic instability in cancer

Britny Blumenfeld, Micha Ben-Zimra, Itamar Simon*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


Cancer and genomic instability are highly impacted by the deoxyribonucleic acid (DNA) replication program. Inaccuracies in DNA replication lead to the increased acquisition of mutations and structural variations. These inaccuracies mainly stem from loss of DNA fidelity due to replication stress or due to aberrations in the temporal organization of the replication process. Here we review the mechanisms and impact of these major sources of error to the replication program.

Original languageAmerican English
Article number1138
JournalInternational Journal of Molecular Sciences
Issue number6
StatePublished - 1 Jun 2017

Bibliographical note

Publisher Copyright:
© 2017 by the authors. Licensee MDPI, Basel, Switzerland.


  • Cancer
  • Genomic instability
  • Replication stress
  • Replication timing


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