Perturbations in the replication program contribute to genomic instability in cancer

Britny Blumenfeld; Micha Ben-Zimra; Itamar Simon

doi:10.3390/ijms18061138

Perturbations in the replication program contribute to genomic instability in cancer

Britny Blumenfeld, Micha Ben-Zimra, Itamar Simon^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

Cancer and genomic instability are highly impacted by the deoxyribonucleic acid (DNA) replication program. Inaccuracies in DNA replication lead to the increased acquisition of mutations and structural variations. These inaccuracies mainly stem from loss of DNA fidelity due to replication stress or due to aberrations in the temporal organization of the replication process. Here we review the mechanisms and impact of these major sources of error to the replication program.

Original language	English
Article number	1138
Journal	International Journal of Molecular Sciences
Volume	18
Issue number	6
DOIs	https://doi.org/10.3390/ijms18061138
State	Published - 1 Jun 2017

Bibliographical note

Publisher Copyright:
© 2017 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Cancer
Genomic instability
Replication stress
Replication timing

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijms18061138

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KW - Replication timing

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Perturbations in the replication program contribute to genomic instability in cancer

Abstract

Bibliographical note

Keywords

UN SDGs

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