Abstract
Cancer and genomic instability are highly impacted by the deoxyribonucleic acid (DNA) replication program. Inaccuracies in DNA replication lead to the increased acquisition of mutations and structural variations. These inaccuracies mainly stem from loss of DNA fidelity due to replication stress or due to aberrations in the temporal organization of the replication process. Here we review the mechanisms and impact of these major sources of error to the replication program.
| Original language | English |
|---|---|
| Article number | 1138 |
| Journal | International Journal of Molecular Sciences |
| Volume | 18 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1 Jun 2017 |
Bibliographical note
Publisher Copyright:© 2017 by the authors. Licensee MDPI, Basel, Switzerland.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Cancer
- Genomic instability
- Replication stress
- Replication timing
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